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New Botox-Like shot could loosen stiff arms in stroke survivors

NCT ID NCT07242300

Symptom relief Sponsor: JHM BioPharma (Tonghua) Co. , Ltd. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 06, 2026 · Updated 3 times

Summary

This Phase 3 trial tests a new botulinum toxin injection called Eveotox in 207 adults with upper limb spasticity (stiff muscles) after a stroke. The goal is to see if it reduces muscle tightness and improves daily tasks like dressing or hygiene compared to a placebo. Participants receive one injection and are followed for safety and effectiveness over several weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Recombinant botulinum toxin type A (Eveotox)
What this could lead to
If it works, this could provide a new treatment option to reduce muscle tightness and improve daily activities like dressing or hygiene for people with post-stroke spasticity.
What could go wrong
This is an early Phase 3 trial with only 207 participants, so results may not apply to everyone. The treatment is temporary and may cause side effects like muscle weakness or injection site reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 207 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant must be 18 to 80 years of age inclusive, at the time of signing the informed consent * Participants with stable post-stroke Spasticity (ULS) for at least 3 months * Participants with Modified Ashworth Scale (MAS) score of at least 2 at elbow flexor or wrist flexor or finger flexor * Participants with DAS score of at least 2 on the Principal Target of Treatment (PTT) (one of four functional domains: dressing, hygiene, limb position and pain) * Participants who have been stable for at least 1 month prior to study entry in terms of oral antispasticity Exclusion Criteria: * Previous use of any botulinum toxin within 6 months prior to screening, or plan to use any botulinum toxin during the study. * History of alcohol or drug abuse. * Known allergy or hypersensitivity to any component of the study products. * History of epilepsy * Known or suspected to be HIV positive, serologically positive for syphilis, or active hepatitis B or C * Any medical condition that may put the participant at increased risk for botulinum toxin type A use

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Upper limb spasticity (ULS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    11 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Tsinghua Changgung Hospital

    NOT_YET_RECRUITING

    Beijing, Beijing Municipality, China

  • Huai 'an Second People's Hospital

    ACTIVE_NOT_RECRUITING

    Huai'an, Jiangsu, China

  • Huashan Hospital Fudan University

    RECRUITING

    Shanghai, Shanghai Municipality, China

  • Luoyang Central Hospital

    RECRUITING

    Luoyang, Henan, China

  • Pingxiang People's Hospital

    RECRUITING

    Pingxiang, Jiangxi, China

  • Shengjing Hospital affiliated to China Medical University

    RECRUITING

    Shenyang, Liaoning, China

  • The Second Affiliated Hospital of Soochow University

    RECRUITING

    Suzhou, Jiangsu, China

  • The Second Affiliated Hospital of Zhengzhou University

    RECRUITING

    Zhengzhou, Henan, China

  • The Second Hospital of Hebei Medical Hospital

    RECRUITING

    Shijiazhuang, Hebei, China

  • The Second Xiangya Hospital of Central South University

    RECRUITING

    Changsha, Hunan, China

  • Yangzhi Affiliated Rehabilitation Hospital of Tongji University

    RECRUITING

    Shanghai, Shanghai Municipality, China

  • Yantai Mountain Hospital

    RECRUITING

    Yantai, Shandong, China

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