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New study pits two endoscopic techniques against each other for stomach blockage relief

NCT ID NCT03259763

Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study looked at 112 adults with stomach blockage caused by advanced cancer. It compared two less invasive procedures: one using an ultrasound-guided bypass and the other using a stent to open the blockage. The goal was to see which method better prevents the blockage from coming back and helps patients eat again.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

112 people

The number who actually took part.

Started

Oct 2020

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients with malignant, symptomatic gastric outlet obstruction due to an unresectable malignant lesion * Gastric outlet obstruction scoring system (GOOSS) score of 0 (no oral intake) or 1 (liquids only) * Age 18-80 years Exclusion Criteria: * Evidence of other strictures in the gastrointestinal (GI) tract * Previous gastric, periampullary or duodenal surgery * World Health Organization (WHO) performance score of 4 (patient is 100% of time in bed) * Unable to fill out quality of life questionnaire * Unable to sign the informed consent * Life expectancy of less than 3 months based on the endoscopist's opinion * Cancer extending into the body of the stomach, 4th portion of the duodenum or proximal jejunum around the ligament of Treitz * Large volume ascites * Inability to tolerate sedated upper endoscopy due to cardiopulmonary instability, severe pulmonary disease or other severe comorbidities * Pregnant or breastfeeding women * Uncorrectable coagulopathy defined by INR \> 1.5 or platelet \< 50000/µl * Complete GOO evidenced by inability to either pass a wire across the stricture and/or inability to opacify small bowel distal to the malignant stricture * Resectable or borderline resectable tumors * One of the two techniques (EUS-GE and ES) cannot be performed (at the discretion of the endoscopist)

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Conditions

The condition(s) this trial relates to.

neoplasm pyloric stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gastric outlet obstruction

Contacts and locations

Locations

  • Asian Institute of Gastroenterology

    Hyderabad, India

  • Ecuadorian Institute of Digestive Diseases (IECED)

    Guayaquil, Ecuador

  • Emek Medical Center

    Afula, 1834111, Israel

  • Hospital Prive des Peupliers

    Paris, France

  • Hospital Universitario Rio Hortega

    Valladolid, 47012, Spain

  • The Johns Hopkins Hospital

    Baltimore, Maryland, 21287, United States

  • The Research Institute of McGill University Health Centre

    Montreal, Quebec, Canada

  • Wake Forest Baptist University

    Winston-Salem, North Carolina, 27157, United States

  • Yale University

    New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.