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Microwave probe delivered through the stomach may heat away Hard-to-Reach tumors

NCT ID NCT07817147

Disease control Sponsor: Banner Health Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are testing a new device that uses endoscopic ultrasound to guide microwave energy directly into pancreatic and liver tumors that cannot be removed by surgery. The study enrolls 75 adults with locally advanced or metastatic cancer. The main goal is to see whether the device successfully delivers energy to the tumor, and the team also tracks safety and any early signs of antitumor effect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
an endoscopic ultrasound-guided microwave ablation device that delivers heat energy directly into tumors
What this could lead to
If it works, this could offer a minimally invasive way to treat hard-to-reach pancreatic and liver tumors without surgery, and it could inform larger trials.
What could go wrong
This is an early feasibility study with 75 participants, so it cannot prove the device extends life or shrinks tumors reliably. The procedure carries risks of bleeding, infection, or damage to nearby organs, and results may not apply to all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female ≥18 years of age * Willing and able to provide written informed consent * Histologically confirmed locally advanced, unresectable or metastatic cancer (Stage III or IV) * At least 1 tumor that is indicated for MWA, and the location of target tumor must be accessible via EUS through the gastric wall (eg, pancreas, liver, etc). * The tumor(s) must be ≥1 cm in diameter Exclusion Criteria: * Participant is a candidate for upfront resection of pancreatic cancer * Participation in another clinical trial that involves local ablation or any other local therapy that could affect the target organ or lesions treated in this study * Any condition that, in the opinion of the investigator, may increase the risk to the participant's safety or well-being

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Conditions

The condition(s) this trial relates to.

liver cancer Liver Neoplasms malignant pancreatic neoplasm Neoplasm Metastasis pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Liver cancer (locally advanced or metastatic) Liver cancer stage IIIA Liver cancer stage IIIB Liver cancer stage IIIC Liver cancer stage IV Pancreatic cancer Pancreatic cancer non-resectable Pancreatic cancer stage III Pancreatic cancer stage IV

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    7 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Banner MD Anderson Cancer Center and Gateway Hospital

    RECRUITING

    Gilbert, Arizona, 85234, United States

  • Cedars Sinai

    NOT_YET_RECRUITING

    Los Angeles, California, 90048, United States

  • Mayo Clinic Rochester

    NOT_YET_RECRUITING

    Rochester, Minnesota, 55905, United States

  • Memorial Hermann-Texas Medical Center

    NOT_YET_RECRUITING

    Houston, Texas, 77030, United States

  • Rush University Medical Center

    NOT_YET_RECRUITING

    Chicago, Illinois, 60607, United States

  • University of Tennessee Medical

    NOT_YET_RECRUITING

    Knoxville, Tennessee, 37920, United States

  • West Virginia University Medicine

    NOT_YET_RECRUITING

    Morgantown, West Virginia, 26506, United States

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