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Essential oil pills: do capsules change how they work?

NCT ID NCT07581522

Knowledge-focused Sponsor: University of Mississippi Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how healthy adults absorb frankincense, lemon, and wild orange essential oils when taken in different types of capsules. Nineteen people took part, and researchers measured oil levels in the blood over 24 hours. The goal was to see if the capsule type changes how fast or how much oil gets into the body, and to check for any safety concerns.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

19 people

The number who actually took part.

Started

Jul 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Selection Criteria: Participants must meet all the following criteria: * Adults ages 18-35 years old * Local to metropolitan Jackson, MS, and/or willing to come to the clinical research center for study visits * Willing to wash out of all internally consumed essential oil and botanical products for at least 2 weeks prior to starting the study and willing to maintain the washout for the duration of the study (approximately 8 weeks) * Willing to avoid all frankincense, wild orange, and lemon essential oil in any form (aromatic, topical, or internal) for the duration of the study (approximately 5 weeks). * Willing to avoid alcohol, recreational drugs, and smoking/vaping for 3 days prior to each arm of the study * Willing to receive an intravenous catheter in the arm or hand every two weeks for 4 weeks (three times total) * History of successful blood/plasma donation, IV insertion, or blood collection by phlebotomy * Weigh at least 110 pounds * No uncontrolled metabolic disease * No unstable major diseases under treatment by healthcare professional * No pregnancy within the last 60 days or currently breastfeeding (females) * No allergy to olive oil or frankincense, lemon, or wild orange essential oils * No regular internal consumption of frankincense, lemon, or wild orange essential oil regularly within the last 1 month (regularly is defined as dosing daily for more than 2 consecutive weeks, or dosing more than 2-3 times per week for 4 consecutive weeks) * No alcohol, recreational drug, or smoking/vaping use in the past 3 days * No evidence of medical condition, significant disease or disorder, medication, or surgery within the past 12 months that may, in the judgment of the medical provider, put the participant at risk or affect study results, procedures, or outcomes * Not currently or previously participating in any other clinical trial within the last 30 calendar days

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Health, subjective Healthy

Contacts and locations

Locations

  • University of Mississippi Medical Center

    Jackson, Mississippi, 39216, United States

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