Could a nasal spray boost PTSD therapy? early trial hints at possibility
NCT ID NCT06795659
First seen Jan 29, 2026 · Last updated Jun 22, 2026 · Updated 20 times
Summary
This small study tested whether adding esketamine (a nasal spray approved for depression) to prolonged exposure therapy could help people with PTSD. Four adults completed 10 daily therapy sessions over two weeks while receiving esketamine. The main goal was to see if the combination was feasible and acceptable, not to prove it works. Early results suggest it may be worth studying further.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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The University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Esketamine (nasal spray)
What this could lead to
If this combination works, it could point toward a faster, more effective way to treat PTSD by enhancing the benefits of therapy.
What could go wrong
This was a very small, early-stage trial with only 4 participants, so results may not apply to others. The study focused on feasibility, not proof of effectiveness.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.