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Second look at 'Abnormal' embryos could unlock hidden IVF potential

NCT ID NCT07227116

Knowledge-focused Sponsor: Shady Grove Fertility Reproductive Science Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is re-testing embryos that were initially found to have three or more abnormal chromosomes (called complex or chaotic aneuploidy). Researchers want to see if some of these embryos are actually normal after a second, more careful biopsy and genetic analysis. If so, they might be usable for IVF. The study involves 280 participants and is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could show that some embryos initially labeled as having many chromosomal errors are actually normal, potentially increasing the number of embryos available for transfer in IVF.
What could go wrong
This is an early observational study, not a treatment trial. It only involves re-testing embryos, not transferring them yet. There is no guarantee that re-tested embryos will be normal or lead to a pregnancy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 280 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2025

An estimate. Start dates often move.

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

All patients with one or more embryos in storage that meet criteria for Chaotic or Complex Aneuploidy by PGT-A with NGS

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Having ≥ 1 embryo classified as whole chromosome chaotic or complex aneuploid of 3 or more chromosomes following preimplantation genetic testing for aneuploidy using an NGS based platform Signed informed consent Exclusion Criteria: * Embryos not meeting complex/chaotic criteria Patients declining consent

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Conditions

The condition(s) this trial relates to.

aneuploidy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chaotic aneuploidy Complex aneuploidy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    12 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fertility Center of Illinois

    RECRUITING

    Highland Park, Illinois, 60035, United States

  • IVF Florida Reproductive Associates

    RECRUITING

    Margate, Florida, 33063, United States

  • SGFertility Chile Medicina Reproductiva

    RECRUITING

    Santiago, Santiago Metropolitan, 7630000, Chile

  • Shady Grove Fertility

    RECRUITING

    Atlanta, Georgia, 30342, United States

  • Shady Grove Fertility

    RECRUITING

    Rockville, Maryland, 20850, United States

  • Shady Grove Fertility

    RECRUITING

    Towson, Maryland, 33607, United States

  • Shady Grove Fertility

    RECRUITING

    Cary, North Carolina, 27519, United States

  • Shady Grove Fertility

    RECRUITING

    Cary, North Carolina, 27519, United States

  • Shady Grove Fertility

    RECRUITING

    Chesterbrook, Pennsylvania, 19087, United States

  • Shady Grove Fertility

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Shady Grove Fertility

    RECRUITING

    Norfolk, Virginia, 23507, United States

  • Shady Grove Fertility

    RECRUITING

    Richmond, Virginia, 23235, United States