Second look at 'Abnormal' embryos could unlock hidden IVF potential

NCT ID NCT07227116

Recruiting now Knowledge-focused Sponsor: Shady Grove Fertility Reproductive Science Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is re-testing embryos that were initially found to have three or more abnormal chromosomes (called complex or chaotic aneuploidy). Researchers want to see if some of these embryos are actually normal after a second, more careful biopsy and genetic analysis. If so, they might be usable for IVF. The study involves 280 participants and is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could show that some embryos initially labeled as having many chromosomal errors are actually normal, potentially increasing the number of embryos available for transfer in IVF.
What could go wrong: This is an early observational study, not a treatment trial. It only involves re-testing embryos, not transferring them yet. There is no guarantee that re-tested embryos will be normal or lead to a pregnancy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aneuploidy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHAOTIC ANEUPLOIDY COMPLEX ANEUPLOIDY

Contacts and locations

Locations

Fertility Center of Illinois
RECRUITING

Highland Park, Illinois, 60035, United States
IVF Florida Reproductive Associates
RECRUITING

Margate, Florida, 33063, United States
SGFertility Chile Medicina Reproductiva
RECRUITING

Santiago, Santiago Metropolitan, 7630000, Chile
Shady Grove Fertility
RECRUITING

Atlanta, Georgia, 30342, United States
Shady Grove Fertility
RECRUITING

Rockville, Maryland, 20850, United States
Shady Grove Fertility
RECRUITING

Towson, Maryland, 33607, United States
Shady Grove Fertility
RECRUITING

Cary, North Carolina, 27519, United States
Shady Grove Fertility
RECRUITING

Cary, North Carolina, 27519, United States
Shady Grove Fertility
RECRUITING

Chesterbrook, Pennsylvania, 19087, United States
Shady Grove Fertility
RECRUITING

Fairfax, Virginia, 22031, United States
Shady Grove Fertility
RECRUITING

Norfolk, Virginia, 23507, United States
Shady Grove Fertility
RECRUITING

Richmond, Virginia, 23235, United States