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Small study tests best epinephrine dose for kids in crisis

NCT ID NCT05327556

Disease control Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study compared two different doses of epinephrine (0.5 vs 1.0 mcg/kg) given to children in the intensive care unit for life-threatening low blood pressure. The goal was to see which dose raised blood pressure more effectively. Only 15 children were enrolled before the study was stopped early.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
epinephrine
What this could lead to
If successful, this could help doctors choose the best dose of epinephrine to quickly raise blood pressure in critically ill children.
What could go wrong
This was a very small, early-phase trial that was terminated early, so results are limited. It only looked at short-term blood pressure changes, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

15 people

The number who actually took part.

Started

Feb 2023

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 25 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female less than 26 years of age. 2. Admitted to BCH and receiving care in a participating ICU. 3. Is prescribed BDE for acute hypotension deemed to be life-threatening in the judgement of the treating clinician. Exclusion Criteria: 1. Has opted out of the study prior to enrollment. 2. Has orders in place which limit resuscitation efforts. 3. Is actively receiving chest compressions while PBE is administered. 4. Is receiving care in the neonatal intensive care unit. 5. Is receiving care outside of the ICU at the time PBE is administered (i.e procedural areas). 6. Is pregnant or breastfeeding. 7. Is a prisoner. 8. Is a ward if the state (DCF custody).

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypotension

Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.