Back pain injection may quietly thin Bones—Study investigates
NCT ID NCT00941473
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This study asks whether epidural steroid injections, commonly used for back pain, can reduce bone density in postmenopausal women. Researchers will track bone turnover markers and bone mineral density in women aged 55–80 over a year after a single injection. The goal is to see if these injections might increase fracture risk and whether preventive steps are needed.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Epidural steroid injection of 80 mg triamcinolone (Kenalog)
- What this could lead to
- If this trial shows a link, it could lead to better counseling and preventive measures for postmenopausal women receiving epidural steroid injections for back pain.
- What could go wrong
- This is a small, early study with only 28 participants, so results may not apply to all women. Also, the study only observes changes, not whether they cause fractures.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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28 people
The number who actually took part.
- Start date
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Jul 2007
- Finished
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Jul 2011
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants were recruited from an orthopedic spine clinic within a large metropolitan health system.
- Ages
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55 to 80 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients with low back pain and have consented to ESI. Age 55 and 5 years postmenopausal Caucasian women. Exclusion Criteria: 1. any women who doesn't meet the inclusion criteria 2. Women with history of a disease affection bone turnover 3. Women taking any drugs known to influence bone metabolism 4. Women who had smoked within the preceding year 5. Women with abnormal serum thyrotropin concentration, or high parathyroid hormone concentratons. 6. Women who had received more than two short courses (lasting 2 weeks or less) of oral or parenteral glucocorticoids in the preceding year or any oral or pareneteral or local (intraarticular, paraspinal,...) or inhaled glucocorticoids in the preceding year 7. Women diagnosed with osteoporosis (T score\<=2.5) on baseline DXA or had history of osteoportic fracture. 8. Pregnant women 9. Severe scoliosis -
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Henry Ford Hospital W. Bloomfield
West Bloomfield, Michigan, 48322, United States