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Epidural pain relief may help gut recovery in liver donors

NCT ID NCT04079673

Knowledge-focused Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at 42 healthy people donating part of their liver. It compared two types of pain relief after surgery: epidural anesthesia (numbing the spine) versus intravenous morphine. The goal was to see how each method affects gut bacteria and how quickly the gut recovers. The findings could help improve recovery for living liver donors.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Patient controlled epidural analgesia (PCEA) with marcaine and fentanyl
What this could lead to
If successful, this could help improve recovery and reduce complications for healthy liver donors after surgery.
What could go wrong
This is a small, completed study with only 42 participants. It focuses on understanding the gut microbiome, not on proving a new treatment works. Results may not apply to other surgeries or populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

42 people

The number who actually took part.

Started

Oct 2019

Finished

Oct 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Expected to receive living liver hepatectomy in National Taiwan University Hospital, age between 20 and 55 years old. Exclusion Criteria: 1. Previous use of antibiotics within four weeks. 2. Previous gastrointestinal surgery.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Living donor hepatectomy

Contacts and locations

Locations

  • Department of Anesthesiology, National Taiwan University Hospital

    Taipei, 100, Taiwan