Can a smartphone app sharpen the mind in early psychosis?
NCT ID NCT05112432
First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This study tests whether a 12-week mobile app program can improve thinking skills and motivation in people with early psychosis. About 400 participants already receiving coordinated specialty care will either use the app or continue standard care. Researchers will track changes in cognition, motivation, and quality of life over 18 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- mobile app-based cognitive and social cognitive training
- What this could lead to
- If it works, this could provide a practical, scalable way to improve thinking skills and motivation for people with early psychosis.
- What could go wrong
- This is a relatively early study without a placebo control, so results may be modest or not generalizable. The app requires consistent use, and benefits may fade over time.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 400 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2021
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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15 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Enrolled in EPI-MINN: Measurement Based Care protocol, STUDY00009334 * Good general health (i.e. not acutely ill or experiencing a severe/chronic illness that would impede their ability to complete study activities. This determination shall be, if necessary, made at the discretion of the PIs) * Estimated IQ at or above 70, as estimated by the Penn CNP Matrix Reasoning Test * Achieved clinical stability, defined as outpatient status for at least one month prior to study participation and clinically stable doses of psychiatric medication (by PI discretion) for at least one month prior to study participation (including no medication) * Has access to a smartphone or other mobile device to use the PRIME app Exclusion Criteria: * Under legal commitment to treatment or is under medical guardianship, and there is no provision in the guardianship order or a court order to allow the guardian to consent to participation in research * Participated in significant cognitive training programs within the last three years * Diagnosed with a neurological disorder (Autism Spectrum Disorder is allowed) * Clinically significant substance abuse that is impeding the participant's abulity to participate fully during recruitment, enrollment, assessment, or training, (is unable to remain sober for assessments and training) * Risk of suicidal behavior, as indicated by the clinicall obtained C-SSRS or clinician judgement. Risk of suicidal behavior is defined as: * Active suicidal ideation at screening or baseline, or * Previous intent to act on suicidal ideation with a specific plan, preparatory acts, or an actual suicide attempt within the last 3 months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hennepin Healthcare
Minneapolis, Minnesota, 55404, United States
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Human Development Center
Duluth, Minnesota, 55805, United States
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University of Minnesota
Minneapolis, Minnesota, 55455, United States
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Other studies related to the condition(s) this trial covers.
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- Can DBT skills ease emotional distress after a first psychotic episode?