New drug EPI-326 takes on tough cancers in first human trial

NCT ID NCT07462377

Recruiting now Disease control Sponsor: EpiBiologics Source: ClinicalTrials.gov ↗

First seen Mar 19, 2026 · Last updated Apr 30, 2026 · Updated 9 times

Summary

This early-phase study tests a new drug called EPI-326 in people with advanced lung cancer (with a specific EGFR mutation) or head/neck cancer. The main goals are to check safety and find the best dose. About 110 participants will receive the drug to see if it can shrink tumors and how the body handles it.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Astera Cancer Care
NOT_YET_RECRUITING

East Brunswick, New Jersey, 08816, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
MD Anderson Cancer Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
START Los Angeles
NOT_YET_RECRUITING

Los Angeles, California, 90025, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Sarah Cannon and HCA Research Institute
NOT_YET_RECRUITING

Nashville, Tennessee, 37203, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
South Texas Accelerated Research Therapeutics (START)
RECRUITING

San Antonio, Texas, 78229, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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EGFR EGFR EPIDERMAL GROWTH FACTOR EPIDERMAL GROWTH FACTOR RECEPTOR EPIDERMAL GROWTH FACTOR RECEPTOR GENE MUTATION HEAD AND NECK HEAD AND NECK CANCER HEAD AND NECK CANCERS HEAD AND NECK CANCERS HEAD AND NECK SQUAMOUS CELL CANCER HEAD AND NECK SQUAMOUS CELL CANCER HEAD AND NECK SQUAMOUS CELL CARCINOMA HEAD AND NECK SQUAMOUS CELL CARCINOMA HEAD AND NECK SQUAMOUS CELL CARCINOMA HNSCC HEAD AND NECK SQUAMOUS CELL CARCINOMA HNSCC HNSCC NON SMALL CELL NON SMALL CELL LUNG CANCER NON-SMALL-CELL LUNG NSCLC (NON-SMALL CELL LUNG CANCER)