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New drug combo shows promise for hard-to-treat endometrial cancer

NCT ID NCT03008408

First seen Nov 21, 2025 · Last updated Jun 12, 2026 · Updated 28 times

Summary

This study tests whether adding ribociclib to the standard combination of everolimus and letrozole can better control advanced or recurrent endometrial cancer. About 90 participants will receive either two or three drugs to see which approach improves tumor shrinkage or stability. The goal is to find a more effective treatment option for people whose cancer has spread or returned.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Lyndon Baines Johnson General Hospital

    Houston, Texas, 77026-1967, United States

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

The condition(s) this trial relates to.

endometrial endometrioid adenocarcinoma endometrium neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.