New colonoscope attachment aims to spot hidden polyps
NCT ID NCT03560037
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether a device called Endocuff Vision, which attaches to the tip of a colonoscope and has soft projections to flatten folds in the colon, can help doctors find more sessile serrated adenomas—a type of precancerous polyp. Over 400 adults undergoing routine screening colonoscopy were randomly assigned to standard colonoscopy or colonoscopy with the device. The goal was to see if the device improves detection of these hard-to-spot polyps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Endocuff Vision (a device with soft projections attached to the colonoscope to flatten folds and improve polyp detection)
- What this could lead to
- If it works, this could help doctors find more precancerous polyps during routine colonoscopies, potentially preventing colon cancer.
- What could go wrong
- This is a completed study, but the device may not significantly improve detection for all types of polyps. Results may not apply to people with prior polyps or other bowel conditions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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427 people
The number who actually took part.
- Started
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May 2019
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * All patients who present to our outpatient gastroenterology suites for screening colonoscopy. Exclusion Criteria: * Age less than 45 and greater than 85 * Prior history of colon polyps (hyperplastic polyp, tubular adenoma or sessile serrated adenoma) and colon cancer * Patients with inflammatory bowel disease * Patients suspected to have colon cancer based on non-invasive tests such as stool tests for hemoglobin or DNA, or imaging finding suggestive of colon cancer (CT or barium enema). * Patients undergoing colonoscopy for evaluation of symptoms such as abdominal pain, rectal bleeding, diarrhea, constipation, etc., or patient with iron deficiency anemia suspected to be due to ongoing bleeding inside the colon * Patients with family history of colon cancer in 1st degree relative below the age of 60 * Patients with family history of hereditary polyposis syndromes such as Lynch syndrome, familial adenomatous polyposis etc., which are associated with an increased risk of colon cancer * Patients unable to consent * Pregnant patients * Incarcerated patients
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California Davis Medical Center
Sacramento, California, 95817, United States