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Spinal fluid proteins may reveal brain recovery in kids

NCT ID NCT07241858

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will check if two proteins found in spinal fluid (NSE and S100B) can help predict how well children with encephalitis (brain inflammation) will recover. Researchers will follow 90 children aged 1 month to 18 years who have symptoms like confusion, seizures, or fever. The goal is to see if these proteins are better than current methods at forecasting outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

1\. Pediatric population aged 1month to 18 years. * Decreased level of consciousness, personality change, or psychiatric manifestations lasting \>24 h (in toddlers and infants, may present as increased irritability or lethargy) * No alternative diagnosis to explain presentation * Seizure (new onset) * Fever (≥38.0°C) * Focal neurologic findings (new onset) * CSF WBC ≥5/mm3 * Acute abnormality on brain MRI

Ages

1 month to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. Pediatric population aged 1month to 18 years. * Decreased level of consciousness, personality change, or psychiatric manifestations lasting \>24 h (in toddlers and infants, may present as increased irritability or lethargy) * No alternative diagnosis to explain presentation * Seizure (new onset) * Fever (≥38.0°C) * Focal neurologic findings (new onset) * CSF WBC ≥5/mm3 Exclusion Criteria: * 1\. Neonates and adults ( \<1 month or \>18 years) 2. If they had a diagnosis of delirium or encephalopathy secondary to sepsis, toxins,renal ,hepatic or metabolic causes (hypoglycemia, electrolyte disturbances

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Conditions

The condition(s) this trial relates to.

encephalitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Encephalitis Encephalitis in children

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Assiut University

    Asyut, Asyut Governorate, 71717, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.