Pre-Surgery blood vessel block may boost colon healing
NCT ID NCT03628248
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This small pilot study tested whether blocking the inferior mesenteric artery with tiny particles 3-4 weeks before rectal or sigmoid colon cancer surgery helps the colon develop extra blood vessels. The goal was to see if this improves blood flow and oxygen supply to the colon during surgery. Only 10 adults with rectal or sigmoid colon cancer took part, and the study focused on measuring blood flow and oxygen levels, not on curing the cancer.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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10 people
The number who actually took part.
- Started
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Mar 2020
- Finished
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Apr 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan * The patient is at least 18 years old and less than 80 years old * Patient has rectal cancer or sigmoid colon cancer requiring surgical treatment Exclusion Criteria: * The subject is participating in another study, or is in a period of exclusion determined by a previous study * The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient is under safeguard of justice or state guardianship * Patient has a history of abdominal surgery * Patient suffers from a hemostasis disorder (hemophilia, von Willebrand disease, thrombocytopenia) and is on anticoagulant therapy. * Patient whose general condition appears too precarious or is taking corticosteroids or immunosuppressants leading to an unacceptable surgical risk. * Renal insufficiency with clearance \<45ml / min * Known allergy to contrast media * Patient who had treatment of the abdominal aorta or its branches Reported pregnancy (the existence of effective contraception will be verified for women of childbearing age). * Anatomical variant at risk or absence of marginal artery highlighted at the time of arteriography. * Abnormality of the superior mesenteric artery * Historic occlusion of the inferior mesenteric artery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Nimes
Nîmes, 30029, France