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New injection targets stubborn love handles

NCT ID NCT07004010

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether injections of deoxycholic acid, sold as Embella, can safely reduce flank fat (love handles). Thirty adults with mild to moderate flank fat received up to 4 ml of the drug over two visits. Researchers measured aesthetic improvement and side effects at 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Deoxycholic acid injection (brand name Embella)
What this could lead to
If it works, this could provide a non-surgical option to reduce flank fat and improve body image.
What could go wrong
This is a small, completed trial with only 30 participants. Results may not apply to everyone, and side effects like swelling or pain are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Aug 2024

Finished

Dec 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Having mild to moderate flank fat assessed by the investigator and sonography and/or caliper (≥2cm thickness of the fat tissue in posterior axillary lines at the level of ASIS) * Signing informed consent by the subject * Ability to follow study instructions and likely to complete all required visits * Agreement to abstain from any treatment to the flank region, including botulinum toxins, hyaluronic acid fillers, cosmetic surgery, laser/light therapy, chemical peels, etc., during the study Exclusion Criteria: * Planning to change lifestyle within the projected duration of the trial * History of liposuction surgery or laser lipolysis in the past 12 months or planning to have these procedures * Significant weight reduction in the past 6 months or planning for weight reduction within the projected duration of the trial * BMI \> 30 kg/m2 * Waist circumference \> 105 cm * Uncontrolled systemic diseases * Severe cardiovascular diseases * Known allergy or sensitivity to the study medication or its components * Females who are pregnant or breastfeeding, or expecting to conceive children within the projected duration of the trial * Current enrollment in an investigational drug or device study or participation in such a study within 30 days of entry into this study and for the duration of the study. * Previous treatment to the flanks with hyaluronic acid fillers or semi-permanent filler in the past 12 months * Use of any permanent filler materials or silicone in the flanks * Subjects planning a cosmetic procedure in the treatment area during the study or with prior cosmetic procedures (i.e., surgery) in the treatment area or visible scars that may affect the evaluation * Subjects with volume deficit due to trauma, abnormalities in adipose tissue related to immune-mediated diseases such as generalized lipodystrophy (e.g., juvenile dermatomyositis), partial lipodystrophy (e.g., Barraquer-Simons syndrome), inherited disease, or HIV-related disease * Infection or dermatoses at the injection site * Evidence of recent alcohol or drug abuse * Medical and/or psychiatric problems that are severe enough to interfere with the study results * Known bleeding disorder or receiving medication that will likely increase the risk of bleeding after injection * Having hair that would interfere with evaluation and treatment of the flank area * Being prone to develop hypertrophic scarring * Having a history of anaphylaxis or allergy to lidocaine (or any amide-based anesthetics), hyaluronic acid products, or Streptococcal protein * Having porphyria * Having an active inflammation, infection, cancerous or precancerous lesion, or unhealed wound in the flank area * Having a condition or being in a situation that, in the investigator's opinion, may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Razi hospital

    Tehran, 11996-63911, Iran