New combo aims to supercharge immune attack on lymphoma

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 to 75 years of age. * ECOG performance of less than 2. * Subjects must have histological confirmation CD30+ lymphoma. * Patients must have at least one line of antitumor therapy * Life expectancy of at least 3 months. * Subjects with lymphoma must have at least one measureable lesion \>1cm as defined by lymphoma response criteria. * Previous treatment must be completed for more than 4 weeks prior to the enrollment of this study, and subjects have recovered to ≤ grade 1 toxicity. * Subjects with autologous hematopoietic stem-cell transplantation are eligible which must be more than 3 months. * Subjects must have adequate marrow, live, renal and heart functions. Exclusion Criteria: * Participants with CD30- lymphoma. * CYP2D6 ultra-rapid metabolizers (URMs). * The patients is taking a CYP2D6 inhibitor and/or concomitantly with a strong or moderate CYP3A inhibitor. * Subjects with a history of severe hypersensitivity reactions to CD30 target immunotherapy. * History of allergy or intolerance to study drug components. * Known brain metastases or active central nervous system (CNS). Subjects with CNS metastases who were treated with radiotherapy for at least 3 months prior to enrollment, have no central nervous symptoms and are off corticosteroids, are eligible for enrollment, but require a brain MRI screening. * Uncontrolled intercurrent illness, including ongoing or active systemic infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia (excluding insignificant sinus bradycardia and sinus tachycardia) or psychiatric illness/social situations and any other illness that would limit compliance with study requirements and jeopardize the safety of the patient. * Known positive test result for human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS). * Previous or concurrent cancer within 3 years prior to treatment start except for curatively treated cervical cancer in situ, non-melanoma skin cancer, superficial bladder tumors \[Ta (non-invasive tumor), Tis (carcinoma in situ) and T1 (tumor invades lamina propria)\]. * Major surgery or trauma occurred within 28 days prior to enrollment, or major side effects have not been recovered. * Vaccination within 30 days of study enrollment. * Active alimentary tract hemorrhage or history of alimentary tract hemorrhage in 1 month. * Pregnant or breast-feeding. Women of childbearing potential must have a pregnancy test performed within 7 days before the enrollment, and a negative result must be documented * Being participating any other trials or withdraw within 4 weeks. * Unable to swallow and retain oral medication, malabsorption syndrome, conditions that significantly impair gastrointestinal function, total gastrectomy or small bowel resection, ulcerative colitis, symptomatic inflammatory bowel disease, partial or complete intestinal obstruction. * Researchers believe that other reasons are not suitable for clinical trials.