New hope for MDS anemia: luspatercept faces off against standard care

NCT ID NCT05949684

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 19 times

Summary

This study tests if luspatercept is better than epoetin alfa at preventing the need for blood transfusions in adults with a certain type of low-risk myelodysplastic syndrome (MDS) who have anemia but haven't needed transfusions yet. About 360 participants will receive one of the two drugs for up to 96 weeks. The goal is to see which drug better controls anemia and delays the need for transfusions.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

ASST Grande Ospedale Metropolitano Niguarda
RECRUITING

Milan, Milano, 20162, Italy

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Advanced Research
RECRUITING

Tamarac, Florida, 33321, United States

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American Oncology Partners, PA
RECRUITING

Bethesda, Maryland, 20817, United States

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Arthur J.E. Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada

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Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia

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Auxilio Mutuo Cancer Center
RECRUITING

San Juan, 00917, Puerto Rico

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Azienda Ospedaliera Ordine Mauriziano di Torino
RECRUITING

Turin, Piedmont, 10128, Italy

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Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, Tuscany, 50134, Italy

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Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma
RECRUITING

Verona, 37134, Italy

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BRCR Global
RECRUITING

Plantation, Florida, 33322, United States

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Baptist MD Anderson Cancer Center
RECRUITING

Jacksonville, Florida, 32207, United States

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Blacktown Hospital
RECRUITING

Blacktown, New South Wales, 2148, Australia

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Blue Ridge Cancer Care
RECRUITING

Roanoke, Virginia, 24014, United States

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Bradfordhill
RECRUITING

Santiago, Santiago Metropolitan, 8420383, Chile

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CHU Bordeaux Haut-Leveque
RECRUITING

Pessac, Aquitaine, 33600, France

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Cancer and Blood Specialty Clinic
RECRUITING

Los Alamitos, California, 90720, United States

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Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
RECRUITING

Vandœuvre-lès-Nancy, Lorraine, 54511, France

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Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau
RECRUITING

Tours, Indre-et-Loire, 37032, France

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Centre Hospitalier Universitaire d'Angers
RECRUITING

Angers, Maine-et-Loire, 49933, France

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Centre Hospitalier Universitaire de Nice - Hôpital l'Archet
RECRUITING

Nice, Alpes-Maritimes, 06202, France

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Centro Medico Barrio Parque
RECRUITING

Buenos Aires, C1425DND, Argentina

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Centro de Investigacion Clinica de Oaxaca
RECRUITING

Oaxaca City, Oaxaca, 68020, Mexico

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Chu Grenoble Alpes
RECRUITING

La Tronche, Isère, 38700, France

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Clínica Inmunocel
RECRUITING

Santiago, Santiago Metropolitan, 7580206, Chile

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Coffs Harbour Health Campus
RECRUITING

Coffs Harbour, New South Wales, 2450, Australia

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Community Cancer Institute
RECRUITING

Clovis, California, 93611, United States

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Compassionate Cancer Care Medical Group
RECRUITING

Fountain Valley, California, 92708, United States

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Enroll SpA
RECRUITING

Santiago, Santiago Metropolitan, 7500587, Chile

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FALP
RECRUITING

Santiago, Santiago Metropolitan, 7500921, Chile

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Fakultni nemocnice Ostrava
RECRUITING

Ostrava, Moravian-Silesian Region, 708 52, Czechia

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Fakultní nemocnice Brno Bohunice
RECRUITING

Brno, Brno-město, 625 00, Czechia

Contact Phone: •••-•••-••••
Florida Cancer Specialists - North
RECRUITING

St. Petersburg, Florida, 33705, United States

Contact Phone: •••-•••-••••
Florida Cancer Specialists - South
RECRUITING

Fort Myers, Florida, 33901, United States

Contact Phone: •••-•••-••••
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, Lombardy, 20122, Italy

Contact Phone: •••-•••-••••
Fondazione Policlinico Tor Vergata
RECRUITING

Rome, Lazio, 00133, Italy

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Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
RECRUITING

Roma, 00168, Italy

Contact Phone: •••-•••-••••
Fundación Cardiovascular de Colombia
RECRUITING

Piedecuesta, Santander Department, 681017, Colombia

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Gemeinschaftspraxis Dres. med. Björn Schöttker & Dominik Pretscher
RECRUITING

Würzburg, 97080, Germany

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Gemeinschaftspraxis für Hämatologie und Onkologie Münster
RECRUITING

Münster, North Rhine-Westphalia, 48153, Germany

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General Hospital of Athens "G. Gennimatas"
RECRUITING

Athens, Attikí, 115 27, Greece

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General Hospital of Athens "Laiko"
RECRUITING

Athens, Attikí, 11527, Greece

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Grande Ospedale Metropolitano - Presidio Morelli
RECRUITING

Reggio Calabria, 89133, Italy

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Gustave Roussy
RECRUITING

Villejuif, Val-de-Marne, 94805, France

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HEMORIO
RECRUITING

Rio de Janeiro, 20211-030, Brazil

Contact Phone: •••-•••-••••
Halifax Health Medical Center
NOT_YET_RECRUITING

Daytona Beach, Florida, 32114, United States

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Hartford Hospital (HH)
RECRUITING

Hartford, Connecticut, 06102, United States

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Hattiesburg Clinic Hematology/Oncology
RECRUITING

Hattiesburg, Mississippi, 39401, United States

Contact Phone: •••-•••-••••
Hematológica Alta Especialidad SC, consultorio 830
RECRUITING

Huixquilucan, 52787, Mexico

Contact Phone: •••-•••-••••
Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet
RECRUITING

Eger, Heves County, 3300, Hungary

Contact Phone: •••-•••-••••
Hospital Británico de Buenos Aires
RECRUITING

Buenos Aires, CP1280AEB, Argentina

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Hospital Clinico de Valencia
RECRUITING

Valencia, Valenciana, Comunitat, 46010, Spain

Contact
Hospital La Princesa
RECRUITING

Madrid, 28006, Spain

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Hospital Pablo Tobon Uribe
RECRUITING

Medellín, Antioquia, 05034, Colombia

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Hospital São Lucas da PUCRS
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

Contact Phone: •••-•••-••••
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, Barcelona [Barcelona], 08035, Spain

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Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33011, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Virgen Del Rocio
RECRUITING

Seville, 41013, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Virgen Nieves
RECRUITING

Granada, 18012, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Walter Cantidio
RECRUITING

Fortaleza, Ceará, 60430-270, Brazil

Contact Phone: •••-•••-••••
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain

Contact Phone: •••-•••-••••
Hospital das Clinicas FMUSP
RECRUITING

São Paulo, 05403-000, Brazil

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Humanitas
RECRUITING

Rozzano, Milano, 20089, Italy

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Hôpital Saint-Louis
RECRUITING

Paris, 75010, France

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IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING

Bologna, 40138, Italy

Contact Phone: •••-•••-••••
InVO Institut für Versorgungsforschung in der Onkologie
RECRUITING

Koblenz, Rhineland-Palatinate, 56068, Germany

Contact Phone: •••-•••-••••
Institut Català d'Oncologia - L'Hospitalet
RECRUITING

L'Hospitalet de Llobregat, Catalunya [Cataluña], 08908, Spain

Contact Phone: •••-•••-••••
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE
RECRUITING

Toulouse, 31100, France

Contact Phone: •••-•••-••••
Instituto Alexander Fleming
RECRUITING

Buenos Aires, C1426ANZ, Argentina

Contact Phone: •••-•••-••••
Instituto Médico de Alta Tecnología S.A.S - IMAT S.A.S
RECRUITING

Montería, 230002, Colombia

Contact
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
RECRUITING

Mexico City, 14080, Mexico

Contact Phone: •••-•••-••••
John Muir Health - Behring Pavilion
RECRUITING

Walnut Creek, California, 94598, United States

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John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States

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Kadlec Clinic Hematology and Oncology
RECRUITING

Kennewick, Washington, 99336, United States

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Kliniken Ostalb, Stauferklinikum
RECRUITING

Mutlangen, 73557, Germany

Contact Phone: •••-•••-••••
Local Institution - 0028
COMPLETED

Berlin, 14195, Germany
Local Institution - 0029
ACTIVE_NOT_RECRUITING

Hangzhou, Zhejiang, 310003, China
Local Institution - 0030
ACTIVE_NOT_RECRUITING

Beijing, Beijing Municipality, 100730, China
Local Institution - 0031
WITHDRAWN

Guangzhou, Guangdong, 450008, China
Local Institution - 0032
ACTIVE_NOT_RECRUITING

Nanjing, Jiangsu, 210029, China
Local Institution - 0033
ACTIVE_NOT_RECRUITING

Wenzhou, Zhejiang, 32500, China
Local Institution - 0034
WITHDRAWN

Hksar, 0, Hong Kong
Local Institution - 0038
ACTIVE_NOT_RECRUITING

Harbin, Heilongjiang, 150010, China
Local Institution - 0043
COMPLETED

Changchun, Jilin, 130021, China
Local Institution - 0048
COMPLETED

Shenyang, Liaoning, 110001, China
Local Institution - 0075
COMPLETED

Chengdu, Sichuan, 610041, China
Local Institution - 0079
ACTIVE_NOT_RECRUITING

Nanchang, Jiangxi, 330006, China
Local Institution - 0083
ACTIVE_NOT_RECRUITING

Suzhou, Jiangsu, 215006, China
Local Institution - 0089
ACTIVE_NOT_RECRUITING

Changsha, Hunan, 410008, China
Local Institution - 0095
WITHDRAWN

Fresno, California, 93703, United States
Local Institution - 0096
WITHDRAWN

Fuzhou Fujian, Fujian, 350001, China
Local Institution - 0097
WITHDRAWN

New Orleans, Louisiana, 70112, United States
Local Institution - 0098
WITHDRAWN

Fort Collins, Colorado, 80528, United States
Local Institution - 0103
ACTIVE_NOT_RECRUITING

Tianjin, Tianjin Municipality, 300020, China
Local Institution - 0108
ACTIVE_NOT_RECRUITING

Wuhan, Hubei, 430058, China
Local Institution - 0109
ACTIVE_NOT_RECRUITING

Hefei, Anhui, 230001, China
Local Institution - 0111
COMPLETED

Qingdao, Shandong, 266003, China
Local Institution - 0117
WITHDRAWN

Sapporo, Hokkaido, 064-0804, Japan
Local Institution - 0118
WITHDRAWN

Sendai, Miyagi, 980-8574, Japan
Local Institution - 0119
WITHDRAWN

Tokyo, 141-8625, Japan
Local Institution - 0120
WITHDRAWN

Sagamihara, Kanagawa, 252-0375, Japan
Local Institution - 0121
WITHDRAWN

Shimotsuga, Tochigi, 321-0293, Japan
Local Institution - 0122
WITHDRAWN

Osaka, 545-8586, Japan
Local Institution - 0123
WITHDRAWN

Kitakyushu-shi, Fukuoka, 8068501, Japan
Local Institution - 0124
WITHDRAWN

Nagasaki, 852-8104, Japan
Local Institution - 0125
WITHDRAWN

Ōsaka-sayama, Osaka, 589-8511, Japan
Local Institution - 0126
WITHDRAWN

Amagasaki, Hyōgo, 660-8550, Japan
Local Institution - 0177
NOT_YET_RECRUITING

Bengaluru, Karnataka, 560027, India

Contact
Local Institution - 0178
ACTIVE_NOT_RECRUITING

Bhubaneswar, Odisha, 751003, India
Local Institution - 0185
WITHDRAWN

Hyderabad, 500034, India
Local Institution - 0186
WITHDRAWN

New Delhi, 110029, India
Local Institution - 0193
COMPLETED

New Delhi, National Capital Territory of Delhi, 110029, India
Local Institution - 0194
ACTIVE_NOT_RECRUITING

Zhengzhou, Henan, 450003, China
Local Institution - 0213
WITHDRAWN

Seattle, Washington, 98133, United States
Local Institution - 0216
ACTIVE_NOT_RECRUITING

Xi’an, Shanxi, 710068, China
Local Institution - 0217
ACTIVE_NOT_RECRUITING

Beijing, Beijing Municipality, 100044, China
Local Institution - 0218
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200030, China
Local Institution - 0220
COMPLETED

Xiamen, Fujian, 361003, China
Local Institution - 0223
COMPLETED

Chongqing, Chongqing Municipality, 400016, China
Local Institution - 0224
COMPLETED

Margate, Florida, 33063, United States
Local Institution - 0230
WITHDRAWN

Daytona Beach, Florida, 32114, United States
Local Institution - 0232
WITHDRAWN

Pikeville, Kentucky, 41501, United States
Local Institution - 0235
COMPLETED

New Delhi, National Capital Territory of Delhi, 110085, India
Local Institution - 0237
WITHDRAWN

San Juan, 00917, Puerto Rico
Local Institution - 0240
NOT_YET_RECRUITING

Honolulu, Hawaii, 96813, United States

Contact
Local Institution - 0242
WITHDRAWN

Pátrai, Achaḯa, 26504, Greece
Local Institution - 0243
ACTIVE_NOT_RECRUITING

Ahmedabad, Gujarat, 380009, India
Local Institution - 0250
WITHDRAWN

Kempten (Allgäu), Bavaria, 87439, Germany
Local Institution - 0255
NOT_YET_RECRUITING

Lübeck, 23562, Germany

Contact
Local Institution - 0261
ACTIVE_NOT_RECRUITING

Erding, Bavaria, 85435, Germany
Local Institution - 0266
ACTIVE_NOT_RECRUITING

Shijiazhuang, Hebei, 050000, China
Local Institution - 0273
WITHDRAWN

Ahmedabad, Gujarat, 382428, India
Local Institution - 0281
COMPLETED

Ningbo, Zhejiang, 315010, China
MTZ Clinical Research powered by Pratia
RECRUITING

Warsaw, 02-172, Poland

Contact Phone: •••-•••-••••
Metro-Minnesota Community Clinical Oncology
RECRUITING

Saint Louis Park, Minnesota, 55426, United States

Contact Phone: •••-•••-••••
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

Contact Phone: •••-•••-••••
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia

Contact Phone: •••-•••-••••
Northwest Cancer Centers, P.C.
RECRUITING

Dyer, Indiana, 46311, United States

Contact Phone: •••-•••-••••
Northwestern Memorial Hospital
RECRUITING

Chicago, Illinois, 60611, United States

Contact Phone: •••-•••-••••
Orchard Healthcare Research Inc.
RECRUITING

Skokie, Illinois, 60077, United States

Contact Phone: •••-•••-••••
Our Lady of the Lake RMC
RECRUITING

Baton Rouge, Louisiana, 70808, United States

Contact Phone: •••-•••-••••
Pindara Private Hospital
RECRUITING

Gold Coast, Queensland, 4217, Australia

Contact Phone: •••-•••-••••
Pontchartrain Cancer Center
RECRUITING

Covington, Louisiana, 70433, United States

Contact Phone: •••-•••-••••
Pratia Onkologia Katowice
RECRUITING

Katowice, 40-519, Poland

Contact Phone: •••-•••-••••
Praxis fur Hamatologie und Onkologie
RECRUITING

Berlin, 10117, Germany

Contact Phone: •••-•••-••••
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia

Contact Phone: •••-•••-••••
Semmelweis Egyetem
RECRUITING

Budapest, 1088, Hungary

Contact Phone: •••-•••-••••
Sociedad De Oncologia Y Hematologia Del Cesar
RECRUITING

Valledupar, Cesar Department, 200001, Colombia

Contact Phone: •••-•••-••••
Specjalistyczny Szpital im. dra Alfreda Sokołowskiego w Wałbrzychu
RECRUITING

Wałbrzych, Lower Silesian Voivodeship, 58-309, Poland

Contact Phone: •••-•••-••••
St. Joseph Hospital
RECRUITING

Orange, California, 92868, United States

Contact Phone: •••-•••-••••
St. Paul's Hospital
RECRUITING

Vancouver, British Columbia, V6Z 1Y6, Canada

Contact Phone: •••-•••-••••
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada

Contact Phone: •••-•••-••••
Szabolcs Szatmár Bereg Vármegyei Oktatókórház
RECRUITING

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary

Contact Phone: •••-•••-••••
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States

Contact Phone: •••-•••-••••
UCLA Hematology/Oncology - Westwood (Building 200 Suite 120)
RECRUITING

Los Angeles, California, 90095, United States

Contact Phone: •••-•••-••••
Unidad Médica Onco-hematológica
RECRUITING

Puebla City, 72424, Mexico

Contact Phone: •••-•••-••••
Universitaetsklinikum Duesseldorf
RECRUITING

Düsseldorf, 40225, Germany

Contact Phone: •••-•••-••••
University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA"
RECRUITING

Chaïdári, Attikí, 12462, Greece

Contact Phone: •••-•••-••••
University General Hospital of Alexandroupoli
RECRUITING

Alexandroupoli, Anatolikí Makedonía Kai Thráki, 681 00, Greece

Contact Phone: •••-•••-••••
University Hospital of Patras
RECRUITING

Pátrai, Achaḯa, 26504, Greece

Contact Phone: •••-•••-••••
University of Tennessee Medical Center
RECRUITING

Knoxville, Tennessee, 37920, United States

Contact Phone: •••-•••-••••
University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-••••
Universitätsklinikum Jena
RECRUITING

Jena, Thuringia, 07747, Germany

Contact Phone: •••-•••-••••
Universitätsklinikum Leipzig
RECRUITING

Leipzig, Saxony, 04103, Germany

Contact Phone: •••-•••-••••
Uniwersyteckie Centrum Kliniczne
RECRUITING

Gdansk, 80-952, Poland

Contact Phone: •••-•••-••••
VCU Health Adult Outpatient Pavillion
RECRUITING

Richmond, Virginia, 23219, United States

Contact Phone: •••-•••-••••
Ventura County Hematology Oncology Specialists
RECRUITING

Oxnard, California, 93030, United States

Contact Phone: •••-•••-••••
Victoria Hospital & Children's Hospital - London Health Sciences Centre
RECRUITING

London, Ontario, N6A 5W9, Canada

Contact Phone: •••-•••-••••
Vseobecna fakultni nemocnice v Praze
RECRUITING

Prague, 12808, Czechia

Contact Phone: •••-•••-••••
Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

Contact Phone: •••-•••-••••

Conditions

Explore the condition pages connected to this study.

MYELODYSPLASTIC SYNDROMES MYELODYSPLASTIC SYNDROMES