Eggshell membrane: the surprising new skin supplement?
NCT ID NCT06148337
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether taking a daily eggshell membrane supplement (uESM) could improve skin elasticity, hydration, and barrier function in 63 healthy adults aged 35-70. Participants took either the supplement or a placebo for a period, and skin measurements were taken using a special device. The goal was to see if this natural ingredient could help protect skin from aging and environmental damage.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- unhydrolyzed eggshell membrane (uESM, Ovolux™ brand)
- What this could lead to
- If it works, this could point toward a natural dietary supplement to help reduce signs of skin aging like firmness and hydration.
- What could go wrong
- This is a small, completed trial with only 63 participants, and results may not apply to everyone. Dietary supplements often show modest effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
63 people
The number who actually took part.
- Started
-
Dec 2023
- Finished
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Jun 2024
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
35 to 70 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subject must be male or female, 35-70 years of age and have a light complexion 2. Subject should be generally healthy and free of chronic skin conditions 3. Subject must be able and willing to give informed consent 4. Subject must be available for and willing to attend all evaluation visits 5. Subject must not have used for 30 days prior to screening and be willing to discontinue use of all topical and ingested products expected to improve the health of the skin, hair, or fingernails for the duration of the study (Examples of these types of medicines are: tretinoin (Retin A®), isotretinoin (Accutane®), hyaluronic acid, collagen, topical steroids, topical antibiotics, topical retinol, topical benzoyl peroxide, topical glycolic acid, topical salicylic acid, etc.) 6. Subject must not be a current smoker and have not smoked cigarettes, cigars, a pipe, etc. for 3 months prior to screening and be willing to remain non-smoking for the duration of the study (the use of 'vape' pens is allowed) 7. Subjects participating in prior studies evaluating eggshell membrane can participate in the current study so long as they are not currently taking an eggshell membrane supplement and have not done so for 90 days prior to screening Exclusion Criteria: 1. Subject has had Botox® or other facial injection (dermal filler) at or near the temple area within 6 months of screening 2. Subject has had facial cosmetic surgery affecting skin elasticity/flexibility (e.g. face lift, etc.) 3. Subject has undergone any medical procedure that would materially affect the appearance, texture or elasticity of skin at or near the evaluation sites (face or arm), as judged by the clinical investigator (e.g. chemical peel, laser resurfacing, dermaplaning, microdermabrasion, etc.) within 6 months prior to screening 4. Subject has a known eating disorder or any dysfunction affecting the digestive tract or the ability to digest food properly 5. Subject is taking any medication or substance known to impact gastric or intestinal motility or the body's ability to break down and utilize foods (i.e., weight loss drugs) 6. Subject has been diagnosed with or experienced within 30 days prior to screening any clinically significant confounding disease or condition that would interfere with the study evaluation, as judged by the clinical investigator (e.g. an allergic response resulting in hives or other skin manifestation, an outbreak of rosacea, a severe sunburn, eczema, psoriasis, skin cancer, etc.) 7. Subject has a known allergy to eggs or egg products. If any subject becomes sensitive during the study, they will immediately be excluded from continuing in the study a. Such sensitivity may be realized as a reaction to inoculations wherein the inoculate is derived from or contains egg components (i.e., influenza vaccine) 8. Subject body weight is greater than 350 pounds (159 kg) 9. Subject is involved in any other research study involving an investigational product (drug, device or biologic) or a new application of an approved product, within 30 days of baseline evaluation 10. Pregnant and breastfeeding women
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Stratum Nutrition National Avenue Clinic
Springfield, Missouri, 65807, United States
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