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Could eggshells help save your jawbone? new trial tests a cheap alternative

NCT ID NCT07404098

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a graft made from eggshell-derived nanohydroxyapatite, combined with a patient's own blood components, can preserve jawbone after a tooth extraction. Thirty-four adults with a hopeless back tooth will receive either this new graft or a standard animal-derived graft. The goal is to see if the eggshell-based option maintains bone density and promotes healing just as well, potentially offering a cheaper and more available alternative.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
eggshell-derived nanohydroxyapatite combined with platelet-rich fibrin
What this could lead to
If successful, this could offer a cheaper, readily available alternative for preserving jawbone after tooth extraction, reducing the need for more complex bone grafts.
What could go wrong
This is a small, early-stage trial with only 34 participants, so results may not apply to everyone. The eggshell-derived material may not work as well as standard grafts, and long-term outcomes are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

Jan 2025

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Inclusion criteria: 1. Patient having at least one hopeless posterior mandibular tooth requires extracted 2. 18 years old or older. 3. Non- smoker 4. Motivated patients with good enough understanding of oral health measurements and importance 5. Medically fit patients. 6. No acute infections, pus formation, socket and bony discharges. 7. Compliant the patient to ensure the follow up * Exclusion criteria: 1. Heavy smokers (more than 10 cigarettes per day or an electronic cigarette dose of \>6 mg/ml of nicotine). 2. Pregnant subjects. 3. Presence of active infection or severe inflammation in the intervention zone. 4. Relevant medical history contraindicates implant surgery. 5. Immunosuppression (e.g.: HIV, solid-organ transplants). 6. Head and neck-irradiated patients in the past 5 years. 7. Regular intake of bisphosphonates, anticoagulants as: aspirin, or anti-inflammatories. 8. Patients with anemia or Thrombocytopenia. 9. Chronic drug abuse or alcoholic habits. 10. Patients with poor oral hygiene (full-mouth plaque score and full-mouth bleeding score \>15%) and lack of motivation. 11. Uncontrolled diabetes (reported levels of glycated hemoglobin exceeding 7%). 12. Uncontrolled and /or untreated periodontal disease (Active Periodontitis). 13. Patients with significant comorbidity such as recent heart attack or coagulation disorder. 14. Patients with a history of allergies. 15. Mentally and physically handicapped patients

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Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone resorption Nano-hydroxyapatite Socket preservation Wound healing

Contacts and locations

Locations

  • Cairo University

    Cairo, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.