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New mouth rinse could improve healing after tooth removal

NCT ID NCT07191262

Disease control Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new EDTA mouth rinse helps wounds heal better after tooth extraction and bone grafting compared to standard chlorhexidine rinse. Forty adults who need a single tooth pulled and bone grafting will use one of two rinses for 12 weeks. Researchers will measure wound closure and plaque buildup to see which rinse works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
EDTA mouth rinse (2.6% and 0.2%) and chlorhexidine (0.12%) and essential oil mouth rinse
What this could lead to
If it works, this could point toward a better mouth rinse for healing after tooth extraction and bone grafting.
What could go wrong
This is a small, early-stage trial with only 40 participants, so results may not apply to everyone. It compares existing rinses, not a new breakthrough treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Able to read and provide informed consent in English * At least 18 years old * Established and registered patient of the UAB School of Dentistry * Patients presenting with one single rooted tooth determined to need extraction and simultaneous ridge preservation bone grafting for future dental implant placement. * Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of the tooth planned for extraction. * No anticipated need for surgical and/or endodontic care at teeth adjacent to the proposed surgical site during the study period. Exclusion Criteria: * Non-English speaking * Age less than 18 years old or older than 85 years old * Smokers/nicotine users (\>10 cigarettes or equivalent/day) * Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing * Multiple adjacent teeth require extraction and grafting * Absence of adjacent teeth/implants on either side of the tooth to be extracted. * Documented or suspected allergy or sensitivity to any study product

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Extraction sites after removal and bone replacement grafting at extraction sockets of dentally hopeless single-rooted teeth

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Alabama at Birmingham

    RECRUITING

    Birmingham, Alabama, 35294-0007, United States