Sweetness and nicotine form in vapes may change how people puff
NCT ID NCT05587504
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested how different e-cigarette liquids—varying in sweetness and nicotine form—affect blood nicotine levels, puffing behavior, and how people feel. Thirteen healthy adults who use cigarettes, e-cigarettes, or both took part. Researchers measured nicotine in the blood, puff volume and duration, and how quickly participants reached for their own product. The goal is to understand how liquid ingredients influence use, which could inform future product design or regulation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- e-cigarette liquid with varying sweetness and nicotine form
- What this could lead to
- If successful, this could help design e-liquids that are less addictive or more satisfying for smokers switching from cigarettes.
- What could go wrong
- This is a very small, early-stage study with only 13 participants, so results may not apply to the general population. It does not test long-term health effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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13 people
The number who actually took part.
- Started
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Jul 2023
- Finished
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Jul 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * healthy (determined by self-report) * between the ages of 18-65 * willing to provide informed consent * use cigarettes, e-cigarettes, or both * able to attend the lab and abstain from tobacco/nicotine as required and must agree to use designated products according to study protocol Exclusion Criteria: * women if they are breast-feeding or test positive for pregnancy (by urinalysis) at screening * existence of any condition contraindicated for this study protocol as determined by study leadership Some study details about the eligibility criteria are purposely omitted at this time to preserve scientific integrity. Full details will be posted at the conclusion of the study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Virginia Commonwealth University
Richmond, Virginia, 23298, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.