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New drug combo aims to stop liver Cancer's return in High-Risk patients

NCT ID NCT03847428

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study tests whether the drugs durvalumab (alone or with bevacizumab) can delay or prevent liver cancer from returning in patients who have had surgery or ablation to remove their tumors. About 900 participants at high risk of recurrence will receive either the drug(s) or a placebo. The main goal is to see how long people stay cancer-free after treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

908 people

The number who actually took part.

Started

Apr 2019

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 150 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histologically or cytologically (or radiologically for patients undergoing curative ablation), newly diagnosed, confirmed HCC and successfully completed curative therapy (resection or ablation) * Imaging to confirm disease-free status within 28 days prior to randomization * ECOG 0-1 at enrolment * Child-Pugh score of 5 or 6 * Adequate organ and marrow function. Exclusion Criteria: * Known fibrolamellar HCC, sarcomatoid HCC or mixed cholangiocarcinoma and HCC * Evidence of metastasis, macrovascular invasion or co-existing malignant disease on baseline imaging * History of hepatic encephalopathy within 12 months prior to randomization * Evidence, by Investigator assessment, of varices at risk of bleeding on upper endoscopy or contrast-enhanced cross-sectional imaging * Patients with Vp1 to Vp4 portal vein thrombosis on baseline imaging are excluded * Active co-infection with HBV and HDV. * Receipt of prior systemic anticancer therapy for HCC * Those on a waiting list for liver transplantation

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma Liver Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hepatocellular carcinoma

Contacts and locations

Locations

  • Research Site

    Birmingham, Alabama, 35233, United States

  • Research Site

    Mobile, Alabama, 36604, United States

  • Research Site

    Phoenix, Arizona, 85054, United States

  • Research Site

    Costa Mesa, California, 92627, United States

  • Research Site

    La Jolla, California, 92093-0698, United States

  • Research Site

    Long Beach, California, 90806, United States

  • Research Site

    Orange, California, 92868, United States

  • Research Site

    Sacramento, California, 95817, United States

  • Research Site

    Washington D.C., District of Columbia, 20007, United States

  • Research Site

    Miami, Florida, 33176, United States

  • Research Site

    Tampa, Florida, 33606, United States

  • Research Site

    Honolulu, Hawaii, 96819, United States

  • Research Site

    Chicago, Illinois, 60637, United States

  • Research Site

    Westwood, Kansas, 66205, United States

  • Research Site

    Louisville, Kentucky, 40206, United States

  • Research Site

    Shreveport, Louisiana, 71103, United States

  • Research Site

    Detroit, Michigan, 48201, United States

  • Research Site

    Grand Rapids, Michigan, 49503, United States

  • Research Site

    Rochester, Minnesota, 55905, United States

  • Research Site

    Omaha, Nebraska, 68198, United States

  • Research Site

    New Brunswick, New Jersey, 08903, United States

  • Research Site

    Albuquerque, New Mexico, 87109, United States

  • Research Site

    New York, New York, 10021, United States

  • Research Site

    Stony Brook, New York, 11794, United States

  • Research Site

    Durham, North Carolina, 27710, United States

  • Research Site

    Winston-Salem, North Carolina, 27157, United States

  • Research Site

    Cleveland, Ohio, 44106, United States

  • Research Site

    Philadelphia, Pennsylvania, 19104, United States

  • Research Site

    Pittsburgh, Pennsylvania, 15212, United States

  • Research Site

    Spartanburg, South Carolina, 29303, United States

  • Research Site

    Knoxville, Tennessee, 37916, United States

  • Research Site

    Memphis, Tennessee, 38104, United States

  • Research Site

    Dallas, Texas, 75216, United States

  • Research Site

    Madison, Wisconsin, 53715, United States

  • Research Site

    Kogarah, 2217, Australia

  • Research Site

    Melbourne, 3004, Australia

  • Research Site

    Nedlands, 6009, Australia

  • Research Site

    Westmead, 2145, Australia

  • Research Site

    Innsbruck, 6020, Austria

  • Research Site

    Linz, 4010, Austria

  • Research Site

    Sankt Pölten, 3100, Austria

  • Research Site

    Florianópolis, 88034-000, Brazil

  • Research Site

    Porto Alegre, 90020-090, Brazil

  • Research Site

    Porto Alegre, 90035-003, Brazil

  • Research Site

    Rio de Janeiro, 20231-050, Brazil

  • Research Site

    Santa Maria, 97015-450, Brazil

  • Research Site

    Santo André, 09060-870, Brazil

  • Research Site

    São José do Rio Preto, 15090-000, Brazil

  • Research Site

    Vitória, 29043-272, Brazil

  • Research Site

    Hamilton, Ontario, L8V 5C2, Canada

  • Research Site

    Kingston, Ontario, K7L 2V7, Canada

  • Research Site

    Ottawa, Ontario, K1H 8L6, Canada

  • Research Site

    Toronto, Ontario, M4N 3M5, Canada

  • Research Site

    Toronto, Ontario, M5G 2M9, Canada

  • Research Site

    Québec, Quebec, G1R 2J6, Canada

  • Research Site

    Beijing, 100021, China

  • Research Site

    Beijing, 100142, China

  • Research Site

    Beijing, 100730, China

  • Research Site

    Bengbu, 233004, China

  • Research Site

    Changchun, 130021, China

  • Research Site

    Changsha, 410013, China

  • Research Site

    Chengdu, 610041, China

  • Research Site

    Fuzhou, 350005, China

  • Research Site

    Guangzhou, 510000, China

  • Research Site

    Guangzhou, 510080, China

  • Research Site

    Guangzhou, 510515, China

  • Research Site

    Hangzhou, 310003, China

  • Research Site

    Hangzhou, 310016, China

  • Research Site

    Hangzhou, 310022, China

  • Research Site

    Harbin, 150049, China

  • Research Site

    Hefei, 230001, China

  • Research Site

    Hohhot, 010010, China

  • Research Site

    Nanjing, 2100008, China

  • Research Site

    Nanjing, 210002, China

  • Research Site

    Ningbo, 315100, China

  • Research Site

    Shanghai, 200032, China

  • Research Site

    Shanghai, 201114, China

  • Research Site

    Shanghai, 201318, China

  • Research Site

    Tianjin, 300170, China

  • Research Site

    Ürümqi, 830000, China

  • Research Site

    Wuhan, 430079, China

  • Research Site

    Xi'an, 710061, China

  • Research Site

    Zhengzhou, 450052, China

  • Research Site

    Alexandria, 21131, Egypt

  • Research Site

    Asyut, 71511, Egypt

  • Research Site

    Cairo, 11451, Egypt

  • Research Site

    Cairo, 11588, Egypt

  • Research Site

    Cairo, 11796, Egypt

  • Research Site

    Dakahlia, 35516, Egypt

  • Research Site

    New Cairo, 11566, Egypt

  • Research Site

    Shebeen El Kom, 32511, Egypt

  • Research Site

    Amiens, 88054, France

  • Research Site

    Angers, 49933, France

  • Research Site

    Besançon, 25000, France

  • Research Site

    Clichy, 92110, France

  • Research Site

    Dijon, 21079, France

  • Research Site

    Nantes, 44093, France

  • Research Site

    Nice, 06200, France

  • Research Site

    Paris, 75571, France

  • Research Site

    Pessac, 33604, France

  • Research Site

    Toulouse, 31059, France

  • Research Site

    Tours, 37049, France

  • Research Site

    Berlin, 13353, Germany

  • Research Site

    Bonn, 53105, Germany

  • Research Site

    Chemnitz, 09116, Germany

  • Research Site

    Cologne, 50937, Germany

  • Research Site

    Freiburg im Breisgau, 79106, Germany

  • Research Site

    Heidelberg, 69120, Germany

  • Research Site

    Leipzig, 04103, Germany

  • Research Site

    Lübeck, 23538, Germany

  • Research Site

    München, 81377, Germany

  • Research Site

    Tübingen, 72076, Germany

  • Research Site

    Hong Kong, 0000, Hong Kong

  • Research Site

    Hong Kong, 150001, Hong Kong

  • Research Site

    Hong Kong, 999077, Hong Kong

  • Research Site

    Hong Kong, Hong Kong

  • Research Site

    Kwai Chung, 999077, Hong Kong

  • Research Site

    Shatin, 00000, Hong Kong

  • Research Site

    Bangalore, 560027, India

  • Research Site

    Bangalore, 560092, India

  • Research Site

    Hyderabad, 500032, India

  • Research Site

    Kolkata, 700160, India

  • Research Site

    Mumbai, 400012, India

  • Research Site

    New Delhi, 110017, India

  • Research Site

    New Delhi, 110076, India

  • Research Site

    New Delhi, 110085, India

  • Research Site

    Bologna, 40138, Italy

  • Research Site

    Milan, 20132, Italy

  • Research Site

    Milan, 20162, Italy

  • Research Site

    Naples, 80131, Italy

  • Research Site

    Roma, 00168, Italy

  • Research Site

    Tricase, Lecce, 73039, Italy

  • Research Site

    Verona, 37134, Italy

  • Research Site

    Bunkyō City, 113-8655, Japan

  • Research Site

    Fukuoka, 810-8563, Japan

  • Research Site

    Gifu, 500-8513, Japan

  • Research Site

    Hiroshima, 734-8551, Japan

  • Research Site

    Kōtoku, 135-8550, Japan

  • Research Site

    Kumamoto, 860-8556, Japan

  • Research Site

    Kurume-shi, 830-0011, Japan

  • Research Site

    Kyoto, 606-8507, Japan

  • Research Site

    Kyoto, 612-8555, Japan

  • Research Site

    Matsuyama, 790-8524, Japan

  • Research Site

    Mitaka-shi, 181-8611, Japan

  • Research Site

    Musashino-shi, 180-8610, Japan

  • Research Site

    Nagasaki, 852-8501, Japan

  • Research Site

    Nagoya, 466-8560, Japan

  • Research Site

    Nagoya, 467-8602, Japan

  • Research Site

    Osaka, 534-0021, Japan

  • Research Site

    Osaka, 541-8567, Japan

  • Research Site

    Osaka, 543-8555, Japan

  • Research Site

    Osakasayama-shi, 589-8511, Japan

  • Research Site

    Sapporo, 006-8555, Japan

  • Research Site

    Sapporo, 060-0033, Japan

  • Research Site

    Sendai, 980-0872, Japan

  • Research Site

    Shinagawa-ku, 142-8666, Japan

  • Research Site

    Shinjuku-ku, 160-0023, Japan

  • Research Site

    Shinjuku-ku, 162-8655, Japan

  • Research Site

    Shiwa-gun, 028-3695, Japan

  • Research Site

    Takasaki-shi, 370-0829, Japan

  • Research Site

    Tsu, 514-8507, Japan

  • Research Site

    Wakayama, 641-8510, Japan

  • Research Site

    Yokohama, 241-8515, Japan

  • Research Site

    Yokohama, 245-8575, Japan

  • Research Site

    Lima, LIMA 31, Peru

  • Research Site

    Lima, LIMA 34, Peru

  • Research Site

    Lima, LIMA 41, Peru

  • Research Site

    San Isidro, 27, Peru

  • Research Site

    City of Muntinlupa, 1780, Philippines

  • Research Site

    Manila, 1000, Philippines

  • Research Site

    Pasig, 1605, Philippines

  • Research Site

    Bydgoszcz, 85-796, Poland

  • Research Site

    Gdansk, 80-952, Poland

  • Research Site

    Poznan, 61-866, Poland

  • Research Site

    Warsaw, 02-034, Poland

  • Research Site

    Ponce, 00716, Puerto Rico

  • Research Site

    Barnaul, 656049, Russia

  • Research Site

    Moscow, 119421, Russia

  • Research Site

    Moscow, 125284, Russia

  • Research Site

    Obninsk, 249031, Russia

  • Research Site

    Saint Petersburg, 197022, Russia

  • Research Site

    Saint Petersburg, 197044, Russia

  • Research Site

    Saint Petersburg, 197758, Russia

  • Research Site

    Yekaterinburg, 620905, Russia

  • Research Site

    Singapore, 119074, Singapore

  • Research Site

    Singapore, 308433, Singapore

  • Research Site

    Singapore, 329563, Singapore

  • Research Site

    Busan, 49241, South Korea

  • Research Site

    Daegu, 41944, South Korea

  • Research Site

    Seoul, 03080, South Korea

  • Research Site

    Seoul, 03722, South Korea

  • Research Site

    Seoul, 05505, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Changhua, 500, Taiwan

  • Research Site

    Tainan, 710, Taiwan

  • Research Site

    Taipei, 10002, Taiwan

  • Research Site

    Taipei, 11217, Taiwan

  • Research Site

    Taoyuan City, 333, Taiwan

  • Research Site

    Yunlin, 640, Taiwan

  • Research Site

    Bangkok, 10210, Thailand

  • Research Site

    Bangkok, 10300, Thailand

  • Research Site

    Bangkok, 10330, Thailand

  • Research Site

    Bangkok, 10700, Thailand

  • Research Site

    Chiang Mai, 50200, Thailand

  • Research Site

    Hat Yai, 90110, Thailand

  • Research Site

    Khon Kaen, 40002, Thailand

  • Research Site

    Pathum Thani, 12120, Thailand

  • Research Site

    Ankara, 06100, Turkey (Türkiye)

  • Research Site

    Ankara, 6200, Turkey (Türkiye)

  • Research Site

    Istanbul, 34098, Turkey (Türkiye)

  • Research Site

    Izmir, 35100, Turkey (Türkiye)

  • Research Site

    Malatya, 44100, Turkey (Türkiye)

  • Research Site

    Hanoi, 100000, Vietnam

  • Research Site

    Hanoi, 123, Vietnam

  • Research Site

    Ho Chi Minh City, 700000, Vietnam

  • Research Site

    Ho Chi Minh City, Vietnam

  • Research Site

    Hochiminh, 70000, Vietnam

More trials for these conditions

Other studies related to the condition(s) this trial covers.