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Could a pill replace your CPAP machine for sleep apnea?

NCT ID NCT06295562

Disease control Sponsor: China Medical University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed phase 4 trial tested three different drug combinations to treat obstructive sleep apnea in 45 adults. The drugs aim to improve how the airway stays open during sleep. Participants took either a drug combo or a placebo before bed, and their sleep was monitored overnight. The main goal was to see if the drugs reduced the number of breathing pauses per hour.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
atomoxetine, oxybutynin, venlafaxine, trazodone
What this could lead to
If successful, these drug combinations could offer a new medication option for people with obstructive sleep apnea who cannot use CPAP machines.
What could go wrong
This is a small, early-phase trial with only 45 participants. The drugs may not work for everyone and could cause side effects like dry mouth or dizziness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

45 people

The number who actually took part.

Started

Nov 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * apnea-hypopnea index ≥ 15 hr-¹ Exclusion Criteria: * the presence of pulmonary, cardiac, neurologic, or other active severe medical or psychiatric diseases * current use of continuous positive airway pressure therapy * use of drugs that might interact with the investigational medication or known to affect sleep during the trial or 1 month before the study * known allergy to the investigational medication * current smoking * heavy alcohol drinking (male \> 14 drinks and women \>7 drinks per week) * pregnant or lactating * periodic limb movement index \> 15hr-1 * the presence of sleep-related hypoventilation

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstructive sleep apnea of adult

Contacts and locations

Locations

  • China Medical University Hospital

    Taichung, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.