Hair loss ointment study halted early – only 4 people enrolled
NCT ID NCT03651752
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a custom ointment called DPCP to help people with severe alopecia areata, a condition causing patchy or complete scalp hair loss. The goal was to see if the ointment could safely regrow hair. Only 4 people took part before the study was stopped early, so results are very limited.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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4 people
The number who actually took part.
- Started
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Apr 2024
- Finished
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Sep 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Subject has clinical diagnosis of extensive alopecia areata (76%-99% involvement as determined by SALT score, Appendix B, Part I). 2. Written informed consent and HIPAA authorization have been obtained. 3. Subject is \> 18 to years of age. 4. Female subjects of childbearing potential have a negative pregnancy test and agree to use an acceptable, highly effective method of birth control (i.e., failure rate of less than 1% per year) to prevent pregnancy. 5. Subject agrees to comply with protocol requirements and attend all required study visits and is considered to be a good study subject. 6. Subject meets concomitant medication washout requirements \- Exclusion Criteria: 1. Subject has \<76 or greater than 99% hair loss. 2. Subject is pregnant or lactating. 3. Subject has current controlled or uncontrolled bacterial, viral (with the exception of herpes simplex), fungal, atypical, or opportunistic infection(s). 4. Subject has a history of substance abuse within the past five years. 5. Immunosuppression (history of transplantation, chemotherapy, splenectomy, HIV). 6. Administration of systemic treatment (e.g., Imuran, biologics) that have an immunomodulatory mechanism of action in the preceding 3 months. 7. Previous treatment with DPCP. 8. Application of topical immunomodulating agent in the preceding 6 weeks. 9. Application of topical or intralesional corticosteroids within the past 6 weeks. 10. Systemic (oral, inhaled, or intravenous) administration of corticosteroid or other systemic treatment (i.e., prednisone) with an immunosuppressive mechanism of action within the past 3 months. 11. Use of light treatments (e.g., PUVA, narrow band UVB) in the preceding 6 weeks. 12. Use of Anthralin in preceding 6 weeks. 13. Use of minoxidil, topical or oral, in the preceding 4 weeks. 14. Subject is currently or has undergone systemic therapy for malignancy within the past five years except for adequately treated Squamous Cell Carcinoma (SCC) or Basal Cell Carcinoma (BCC) of the skin. 15. Clinical evidence of secondary skin infection (i.e., folliculitis). 16. Participation in other therapeutic investigational clinical trials within 4 weeks of enrollment. 17. Evidence of anemia, thyroid disease, sarcoidosis or other medical condition that could be adversely affected by participating in the study. 18. Subject has any medical condition that, in the judgment of the Investigator, would jeopardize the subject's safety following exposure to the administered medications. \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Minnesota Department of Dermatology
Minneapolis, Minnesota, 55455, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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