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New study tests safer blood thinners for Clot-Prone patients

NCT ID NCT07372170

First seen Jan 31, 2026

Summary

This study looks at two types of blood thinners—direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs)—to see which works better at preventing repeat blood clots in people with a low-risk form of antiphospholipid syndrome (APS). APS is an autoimmune condition that raises the risk of dangerous clots. Researchers will follow 600 adults already taking one of these medications in routine care, tracking clot recurrences and bleeding events. The goal is to provide real-world evidence on whether newer DOACs are a safe option for these patients.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Hospital Universitario Infanta Leonor

    RECRUITING

    Madrid, Madrid, 28031, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Universitario Infanta Sofía

    RECRUITING

    Madrid, Madrid, Spain

    Contact Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs)

What this could lead to

If successful, this study could clarify whether DOACs are a safe and effective alternative to standard blood thinners for preventing repeat clots in low-risk antiphospholipid syndrome patients.

What could go wrong

This is an observational study, not a controlled trial, so results may be influenced by patient selection or other factors. It cannot prove cause and effect, and findings may not apply to higher-risk patients.

Conditions

The condition(s) this trial relates to.

antiphospholipid syndrome thrombophilia thrombophilia due to thrombin defect Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.