Blood thinner timing after polyp removal: sooner may be safe
NCT ID NCT06482333
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether restarting blood thinners (DOACs) right after colonoscopy polyp removal is as safe as waiting two days. About 194 adults on DOACs who need a colonoscopy will be randomly assigned to restart their medication on the same day or two days later. The goal is to compare bleeding and clot risks between the two groups.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Direct Oral Anticoagulants (DOACs)
- What this could lead to
- If early resumption is safe, patients on blood thinners may be able to restart their medication sooner after polyp removal, reducing their risk of blood clots.
- What could go wrong
- This is a small, early-phase trial (194 participants) testing timing only, not a new treatment. The results may not apply to all patients or procedures.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 194 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2024
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- All adult patients who are taking DOACs and schedule for elective colonoscopy are potentially eligible. We only included patients who had complete colonoscopy and with polypectomy performed. Exclusion Criteria: * Previous resection of any colonic segments, * Inflammatory bowel disease or polyposis syndrome * Patient with large polyp required advanced procedure e.g. endoscopic submucosal dissection (ESD) to remove * Patients who develop immediate post-polypectomy bleeding during the procedure and requiring haemostasis will also be excluded * Patient without polypectomy * Patient without complete colonoscopy done
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Queen Mary Hospital, the University of Hong Kong
RECRUITINGHong Kong, Hong Kong