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New blood clot pill could replace daily shots after joint replacement

NCT ID NCT07124819

First seen Jan 20, 2026 · Last updated May 22, 2026 · Updated 11 times

Summary

This study tested whether an oral drug called Dimolegin is as safe and effective as standard heparin injections (Clexane) for preventing dangerous blood clots after hip or knee replacement. 215 adults undergoing elective joint replacement took either the pill or the injection. The study measured how many people developed blood clots, had bleeding complications, or died from any cause. Results will help determine if a simple pill can replace daily shots for clot prevention after major joint surgery.

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Contacts and locations

Locations

  • Bryansk City Hospital No. 1

    Bryansk, Russia

  • I.M. Sechenov First Moscow State Medical University (Sechenov University)

    Moscow, Russia

  • National Research Ogarev Mordovia State University

    Saransk, Russia

  • Privolzhsky Research Medical University

    Nizhny Novgorod, Russia

  • Rostov State Medical University

    Rostov-on-Don, Russia

  • Ryazan State Medical University named after academician I.P. Pavlov

    Ryazan, Russia

  • Samara Regional Clinical Hospital named after V.D. Seredavin

    Samara, Russia

  • Saratov State Medical University named after V. I. Razumovsky

    Saratov, Russia

Conditions

Explore the condition pages connected to this study.