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Diesel fumes and your heart: what a small study found

NCT ID NCT01548625

Knowledge-focused Sponsor: Environmental Protection Agency (EPA) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested how breathing different levels of diesel exhaust affects the heart and blood vessels in 6 healthy adults aged 50-75. Each person breathed in diesel fumes at three different strengths for 2 hours, with breaks in between. Researchers used ultrasound to check blood vessel function. The goal was to understand how air pollution might raise heart risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diesel exhaust
What this could lead to
If successful, this could help explain how air pollution harms the heart and guide future health recommendations.
What could go wrong
This is a very small, early study with only 6 healthy people. Results may not apply to others, and it does not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

6 people

The number who actually took part.

Start date

Jul 2007

Finished

Nov 2008

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy 50-75 year-old male and female subjects with GSTM1 null genotype.

Ages

50 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 50-75 years old generally healthy male and female. * Normal resting ECG. * Oxygen saturation greater than 94% at the time of physical exam. Exclusion Criteria: * A history of angina, cardiac arrhythmias, and ischemic myocardial infarction or coronary bypass surgery. * Cardiac pacemaker. * Uncontrolled hypertension (\> 150 systolic, \> 90 diastolic). * Neurodegenerative diseases such as Parkinson's and Alzheimer disease. * A history of chronic illnesses such as diabetes, cancer, rheumatologic diseases, immunodeficiency state, known cardiovascular disease, chronic respiratory diseases such as chronic obstructive pulmonary disease or severe asthma. * History of bleeding diathesis. * Currently taking HMG-CoA reductase inhibitors for hyperlipidemia including lovastatin, pravastatin, simvastatin, and atorvastatin. * Currently taking beta-blockers to control hypertension and/or arrhythmias. * Use of oral anticoagulants. * Participants must refrain from all over-the-counter NSAIDs for a period of two weeks prior to exposure. Low-dose aspirin will be acceptable. Medications not specifically mentioned here may be reviewed by the investigators prior to a participant's inclusion in the study. * Subjects who are currently smoking or have smoking history within 1 year of study (defined as more than one pack of cigarettes in the past year). * Subject is pregnant, attempting to become pregnant or breastfeeding. * No exposure will be conducted within 4 weeks of a respiratory tract infection.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • EPA Human Studies Facility

    Chapel Hill, North Carolina, 27599, United States

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