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Brain scans reveal how common sedatives alter memory

NCT ID NCT00696033

Knowledge-focused Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This completed study gave 22 healthy volunteers a single dose of diazepam, lorazepam, or a placebo, then used brain scans to see how these drugs affect memory and perception. The goal was to understand why lorazepam may impair unconscious memory more than diazepam. The findings could help doctors use these medications more safely.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
diazepam and lorazepam (single oral doses)
What this could lead to
If successful, this could help explain how benzodiazepines affect memory and perception, guiding safer use of these drugs.
What could go wrong
This is a small, early-phase study in healthy volunteers, not patients. Results may not apply to real-world medical use or predict long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

22 people

The number who actually took part.

Start date

Jul 2007

Finished

Dec 2008

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy subjects between 18 and 30 years * Students in medicine, dentistry or pharmacy * French as a mother language Exclusion criteria: * Medical condition influencing brain function (neurological or psychiatric) * Asthma * General anesthesia in the 3 last months * Drug addiction (DSM IV criteria) * Regular medical treatment (except contraceptive pill) * Significant impairment observed during a medical examination including ECG * Intake of any psychotropic drug that can have a effect during testing * IQ (Wechsler) \< 100 * FMRI contra-indication (implantable magnetic material, claustrophobia) * Known allergy to benzodiazepine or lactose * \> 10 cigarettes/day * Pregnant or breast-feeding woman * No health insurance * Subjects who do not complete the entire study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy subjects

Contacts and locations

Locations

  • Centre d'investigation clinique, hôpital civil

    Strasbourg, 67091, France

  • Clinique psychiatrique, hôpital civil

    Strasbourg, 67091, France

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