Cataract surgery pain relief: which additive works best?
NCT ID NCT07671066
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding dexmedetomidine or dexamethasone to a local anesthetic mixture improves pain control and patient satisfaction during cataract surgery. 75 adults undergoing eye surgery received one of the two additives or a placebo. The main goal was to see how long it took before patients needed extra pain relief after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dexmedetomidine, Dexamethasone, Normal saline
- What this could lead to
- If it works, this could point toward a better way to manage pain during and after cataract surgery, potentially reducing the need for strong painkillers.
- What could go wrong
- This is a small, completed study with only 75 participants, so results may not apply to everyone. The drugs are already used in other settings, so no major new breakthrough is expected.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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75 people
The number who actually took part.
- Started
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Dec 2024
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age: \> 18 years old. * Sex: Male \& Female * American Society of Anesthesiologists (ASA) Physical status I -III. * Patients undergoing ophthalmic surgery under local anesthesia. Exclusion Criteria: * Patients' refusal. * Patients have active ocular infection. * Patients have single eyes. * Allergy to thesis medications (mainly bupivacaine and lidocaine). * Patients cannot lie flat. * Patient on anticoagulation. * Abnormal coagulation profile in the form of international normalized ratio (INR) ≥1.6
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Helwan University
Helwan, 11795, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A lens that could let cataract patients see near and far without glasses
- One operation for cataract and glaucoma? eye surgeons test a Two-in-One approach
- Can a common steroid stretch spinal anesthesia and keep surgery patients comfortable longer?
- Can a sedative plus ear stimulation stop PTSD before it starts?
- Can a Nerve-Blocking injection prevent salivary complications after parotid surgery?
- Eye drops may shield the cornea after cataract surgery