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Could a tiny dose of dexmedetomidine double Pain-Free time after surgery?

NCT ID NCT07651488

Symptom relief Sponsor: Liaquat National Hospital & Medical College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether adding a small dose of dexmedetomidine to a standard spinal anesthetic (bupivacaine) can extend pain relief for adults undergoing perianal surgery. One hundred participants aged 40–80 will receive either the standard anesthetic alone or with dexmedetomidine. The main goal is to see how long pain relief lasts and whether it reduces the need for additional pain medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexmedetomidine
What this could lead to
If it works, this could provide longer-lasting pain relief after perianal surgery, reducing the need for additional painkillers.
What could go wrong
This is a very early-phase trial with only 100 participants, so results may not apply broadly. Adding dexmedetomidine may also increase side effects like drowsiness or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

100 people

The number who actually took part.

Started

Mar 2023

Finished

Sep 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing elective perianal surgery under spinal saddle block were included in the study. * Age between 40-80 years * ASA status I and II Exclusion Criteria: * Pregnant women * Patient with coagulopathy * Infection at or near the needle insertion site * Allergy to the trial drug * Patient with chronic pain * Cognitive impairment * Patient with known drug or substance abuse

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Duration of analgesia Pain score

Contacts and locations

Locations

  • Liaquat National Hospital

    Karachi, Pakistan

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