Can a simple IV drug combo extend pain relief after hand surgery?
NCT ID NCT07531407
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at whether giving dexamethasone or ibuprofen through an IV before hand or forearm surgery could make the nerve block pain relief last longer. 79 adults were enrolled and received one of the two drugs before their procedure. Researchers also tracked nausea and vomiting in the first 24 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dexamethasone and ibuprofen
- What this could lead to
- If effective, this could offer a simple way to prolong pain relief after hand or forearm surgery without strong opioids.
- What could go wrong
- This is a small, completed study with 79 participants, so results may not apply widely. Both drugs have known side effects like nausea or allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
79 people
The number who actually took part.
- Started
-
May 2025
- Finished
-
Oct 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients aged between 18 and 65 years, with ASA physical status I or II, who were scheduled for hand or forearm surgery, were included in the study.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient's consent to participate in the study (Informed consent) * Aged between 18 and 65 years * ASA physical status I or II * Being oriented and cooperative * Scheduled to undergo hand or forearm surgery * Body Mass Index (BMI) below 40 kg/m² * Scheduled for axillary brachial plexus blockade Exclusion Criteria: * Patient's refusal to participate in the study * Refusal of regional anesthesia * Known allergy to local anesthetics * Known allergy to ibuprofen * Known allergy to dexamethasone * Presence of coagulopathy * Local infection at the site of regional anesthesia application * Presence of malignancy at the surgical site * Diagnosis of diabetes mellitus * Body Mass Index (BMI) of 40 kg/m² or above * Duration of surgery exceeding 4 hours * Administration of opioid medication during the preoperative or intraoperative period
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Prof. Dr. Cemil Tascioglu City Hospital
Istanbul, 34384, Turkey (Türkiye)
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Other studies related to the condition(s) this trial covers.
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