Can a steroid or cold water ease tooth pain after root treatment?
NCT ID NCT07233577
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 72 adults with a painful tooth condition called irreversible pulpitis. During a dental procedure to remove the infected pulp, researchers tested whether rinsing the tooth with a dexamethasone solution or cold saline could reduce pain afterward. The goal was to find a simple way to make recovery more comfortable.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dexamethasone
- What this could lead to
- If it works, this could offer a simple way to reduce pain after dental pulp treatment, improving patient comfort.
- What could go wrong
- This is a small, completed study with 72 participants, so results may not apply to everyone. Pain relief may be modest or not better than standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
72 people
The number who actually took part.
- Started
-
Dec 2024
- Finished
-
Jun 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Vital permanent molars exhibiting positive responses to both the cold test and the electric pulp test, with a prolonged cold response (\>30 seconds) consistent with symptomatic irreversible pulpitis. * Presence of deep carious lesions in the included teeth (indicated for vital pulp therapy). * No radiographic evidence of periapical pathology (i.e., no periapical radiolucency, root resorption, or pathological widening of the periodontal ligament space). * Patients who had not taken analgesics or antibiotics during the 24 hours preceding the procedure. Exclusion Criteria: * Devital permanent molars that responded negatively to cold tests and electric pulp tests * Permanent molars with poor periodontal status (pocket depth \> 4 mm), * Teeth that exhibited periapical radiolucency, pathological mobility, or were deemed non-restorable * Systemic diseases, pregnancy or lactation, known allergies to dexamethasone or NSAIDs, recent use of analgesics (within 24 hours), and any contraindications for pulpotomy or local anesthesia
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cukurova University
Adana, Sarıçam, 01250, Turkey (Türkiye)
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