Common steroid may boost pain relief after spine surgery
NCT ID NCT07429708
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding the steroid dexamethasone to a standard nerve block could reduce pain and inflammation after lumbar laminectomy (back surgery). Thirty-six adults undergoing surgery received either the nerve block with dexamethasone or without. The dexamethasone group had longer pain relief, lower pain scores, and less need for opioid painkillers. The results suggest dexamethasone may be a useful addition to improve recovery after spine surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dexamethasone
- What this could lead to
- If it works, this could provide a simple, low-cost way to improve pain control and reduce opioid use after back surgery.
- What could go wrong
- This is a small, single-center trial with only 36 participants. Results may not apply to all patients, and dexamethasone carries risks like infection or blood sugar changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
36 people
The number who actually took part.
- Started
-
Mar 2025
- Finished
-
Sep 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients aged between 18 - 65 years * ASA physical status I-III * Patients with a BMI of 18 - 30 kg/m2 Exclusion Criteria: * Patients with contraindications to regional anesthesia * Infection at the puncture site * Type 2 Diabetes Mellitus (T2DM) * Hypersensitivity or allergy to the medications used * Prolonged or chronic opioid use * Laminectomy involving more than two segments * Inability to be assessed using the Visual Analogue Scale (VAS) or to operate the PCA device
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ngoerah General Hospital
Denpasar, Bali, 80113, Indonesia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Simple tube after spine surgery may cut complications
- New nerve block technique aims to cut opioid use after back surgery