Could a common steroid prevent brain damage after carbon monoxide poisoning?
NCT ID NCT06574048
First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 1 time
Summary
This early study tests whether adding the steroid dexamethasone to standard hyperbaric oxygen therapy helps prevent long-term brain problems after carbon monoxide poisoning. Twenty adults who receive hyperbaric oxygen will be randomly given either dexamethasone or a placebo. Researchers will track their thinking, memory, and emotions over time to see if the steroid improves recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dexamethasone
- What this could lead to
- If it works, this could point toward a simple, low-cost way to reduce long-term brain damage after carbon monoxide poisoning.
- What could go wrong
- This is a very small, early pilot study with only 20 people. It may not show a clear benefit, and steroids carry risks like infection or blood sugar changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Acute CO poisoning, intentional or non-intentional exposure, receiving HBO treatment during hospitalization * Age \>18 years * Nebraska Medicine admission Exclusion Criteria: * Mechanical ventilation * No hospital admission or admission to hospital Critical Care Medicine Service * Allergy to dexamethasone * Pre-Existing neurological condition confounding outcome determination
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Nebraska Medicine, Hyperbaric Medicine Program, Clarkson Tower
Omaha, Nebraska, 68105, United States
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