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Could a simple steroid unblock bowels and avoid surgery?

NCT ID NCT07084441

Symptom relief Sponsor: University of Washington Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a short course of the steroid dexamethasone to standard supportive care helps more people recover from an adhesive small bowel obstruction without needing surgery. About 550 adults with this condition will be randomly assigned to receive either dexamethasone plus supportive care or supportive care alone. The main goal is to see if the drug increases the chance of the blockage resolving on its own.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 550 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥18 years of age recruited from UWMC * Patients presenting to surgical services through the Emergency Department, diagnosis of SBO, consulted by surgeon, and an urgent or emergency operation is deemed not necessary by surgeon. * Diagnosis of aSBO is established by; 1. CT findings consistent with diagnosis of SBO; and 2. signs and symptoms consistent with SBO; and 3. Adhesions from prior abdominopelvic surgery are the likely cause of SBO (absence of incarcerated hernia, internal hernia, masses, fistula, stricture, volvulus, acute episode of inflammatory bowel disease (IBD) flare, etc.). * Ability to provide written or electronic informed consent in English and answer teach-back questions Exclusion Criteria: * Signs and symptoms of peritonitis with emergency operation planned * Planned urgent operation within the next 12 hours * Allergy to dexamethasone * Surgery within prior 6 weeks * Unable or unwilling to return or be contacted for and/or complete research surveys * Currently incarcerated in a detention facility or in police custody (patients wearing a monitoring device can be enrolled) at baseline/screening * Individuals with latent infections who have an increased risk of infection.

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Conditions

The condition(s) this trial relates to.

intestinal obstruction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adhesive small bowel obstruction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Columbia University Medical Center

    RECRUITING

    New York, New York, 10032, United States

  • Harborview Medical Center

    RECRUITING

    Seattle, Washington, 98104, United States

  • UW Medical Center - Northwest

    RECRUITING

    Seattle, Washington, 98133, United States

  • University of Washington Medical Center Montlake

    RECRUITING

    Seattle, Washington, 98195, United States

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