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Can a computer program lift veterans out of depression?

NCT ID NCT06217198

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests whether Deprexis, a self-guided online program, can reduce depressive symptoms and improve daily functioning in veterans with mild to moderate depression. Participants will use the 12-module program over 8 weeks, and their progress will be compared to those receiving usual care. The goal is to see if this accessible, remote intervention can be a helpful option for veterans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Deprexis, an internet-delivered, self-guided behavioral intervention with 12 interactive modules for depression
What this could lead to
If effective, Deprexis could offer veterans a convenient, remote treatment option to reduce depressive symptoms and improve daily functioning.
What could go wrong
The trial is relatively small and early, and results may not generalize. As a self-guided program, engagement and adherence could vary, and it may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 152 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Apr 2029

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Potential participants include male and female Veterans of all races/ethnicities who are: * able to comprehend and sign the informed consent form * have reliable access to the internet and a computer, tablet and/or smartphone * exhibit mild or moderate, but not very severe, levels of depression * stable on psychotropic medications Exclusion Criteria: Aim 1 and Aim 2: Veterans will be excluded from study participation if they: * endorse any positive symptoms of a psychotic disorder * screen positive for Bipolar I Disorder * report current suicidal risk

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Depression

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX

    RECRUITING

    Waco, Texas, 76711, United States

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