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VR task reveals how depression drains motivation

NCT ID NCT06648460

Knowledge-focused Sponsor: Georgia Institute of Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 2 times

Summary

This study uses a virtual reality task to measure how people with depression make decisions involving physical effort and reward. Participants will walk on a treadmill in a VR environment while researchers track brain activity, heart rate, and energy use. The goal is to better understand why depression makes it hard to put in effort, which could lead to improved ways to assess and treat motivation problems.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better ways to measure and understand motivation problems in depression, potentially improving diagnosis and treatment approaches.
What could go wrong
This is an early observational study with only 90 participants, so results may not apply to everyone with depression. It measures behavior and brain activity, not a treatment, so direct benefits are limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Matched control group * 18-65 years old * Able-bodied * Fluent in English * Able to give written and verbal informed consent to the proposed experiment * Able to comprehend the study procedure, potential risks, and benefits * Group with depression * Diagnosed with major depression * Quick Inventory of Depression Symptomology (QIDS) score \> 5 * 18-65 years old * Able-bodied * Fluent in English * Able to give written and verbal informed consent to the proposed experiment * Able to comprehend the study procedure, potential risks, and benefits Exclusion Criteria: * Matched control group * Current diagnosed psychiatric disorder (e.g., anxiety, depression, bipolar disorder) * Current pregnancy * BMI \> 35 * Currently on antipsychotics * Group with depression * Diagnosed with psychotic symptoms * Diagnosed with other neurological or psychiatric disorders * Current pregnancy * BMI \> 35 * Currently on antipsychotics

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Conditions

The condition(s) this trial relates to.

Anhedonia Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anhedonia Depression

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Georgia Tech Manufacturing Institute

    Atlanta, Georgia, 30308, United States

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