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Could depression change how Kids' asthma responds to treatment?

NCT ID NCT04617015

Knowledge-focused Sponsor: State University of New York at Buffalo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 39 children with asthma to see if those with depression have a different type of airway response. Researchers tested whether an anticholinergic inhaler (ipratropium) works better in depressed versus non-depressed children. The goal was to better understand this possible asthma subtype, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ipratropium Bromide (an anticholinergic inhaler)
What this could lead to
If successful, this could point toward a personalized treatment approach for children with asthma and depression, using a different type of inhaler.
What could go wrong
This is a very small, early-phase study with only 39 participants. It is designed to gather information, not to prove a treatment works. Results may not apply to all children with asthma and depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

39 people

The number who actually took part.

Started

Sep 2016

Finished

Mar 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

7 to 17 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of asthma * Decreased lung volumes for age/height/race (FEV1 \<80% predicted or ratio of FEV1 to forced vital capacity (FVC) \< 85%) on day of study visit assessed by spirometry. Exclusion Criteria: * Severely developmentally delayed patients, or those who suffer from other severe cognitive impairment not allowing them to perform spirometry or participate in study instruments. * Patients who are pregnant or nursing. * Patients with significant cardiopulmonary disease other than asthma, including cystic fibrosis, alpha-1-antitrypsin deficiency, interstitial lung disease, tracheo-/bronchomalacia, or cyanotic congenital cardiac defect. * Patients with glaucoma, myasthenia gravis, or bladder neck obstruction (anticholinergics can worsen these conditions). * Patients currently taking another anticholinergic medication

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Conditions

The condition(s) this trial relates to.

asthma childhood onset asthma Depression depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthma Childhood asthma Depression

Contacts and locations

Locations

  • Women and Children's Hospital of Buffalo

    Buffalo, New York, 14222, United States

More trials for these conditions

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