Could a simple gel replace surgery for HPV-Related cervical changes?
NCT ID NCT05509413
First seen Nov 18, 2025 · Last updated Jun 23, 2026 · Updated 30 times
Summary
This study tested whether a vaginal gel called DEFLAGYN, made from silica and citric acid, can help women with unclear cervical smears and high-risk HPV infections clear the virus and avoid surgery. 242 women used the gel for 3 months. The goal was to see if the gel increases the rate of HPV clearance and regression of abnormal cells compared to waiting without treatment.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
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Locations
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Marien Hospital Herne
Herne, North Rhine-Westphalia, 44625, Germany
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
DEFLAGYN vaginal gel (silica and citric acid)
What this could lead to
If it works, this could offer a non-surgical, wait-and-see option for women with unclear cervical smears and high-risk HPV, potentially reducing the need for procedures like conization.
What could go wrong
This is a completed study with limited prior evidence. The gel is a medical device, not a drug, and its effect may be modest. Side effects were not observed in a prior small trial, but larger studies are needed to confirm benefits.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.