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Cancer drug trial halted early: no breakthrough for advanced tumors

NCT ID NCT04892017

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 36 times

Summary

This early-stage trial tested a new drug, DCC-3116, alone or with other targeted therapies, in 91 adults with advanced solid tumors (like lung cancer) that have specific gene mutations. The study was terminated, meaning it stopped early, likely due to safety or lack of benefit. The goal was to find safe doses and see if tumors shrank, but this is not a cure—patients would need ongoing treatment.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

    New York, New York, 10016, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • NEXT Oncology

    Austin, Texas, 78758, United States

  • NEXT Oncology

    San Antonio, Texas, 78229, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Rutgers Cancer Institute

    New Brunswick, New Jersey, 08901, United States

  • The University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • University of Wisconsin Clinical Science Center

    Madison, Wisconsin, 53792, United States

  • Washington University Siteman Cancer Center

    St Louis, Missouri, 63108, United States

Conditions

Explore the condition pages connected to this study.