Could a multiple sclerosis drug help people with parkinsonism walk better?
NCT ID NCT07682428
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study looks at whether dalfampridine, a drug already used for walking problems in multiple sclerosis, can improve mobility in people with vascular parkinsonism or Parkinson-plus syndromes. Participants who do not respond well to standard levodopa treatment will receive dalfampridine or continue usual care for four weeks. Researchers will measure changes in walking speed, balance, and daily function to see if the drug helps.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dalfampridine
- What this could lead to
- If successful, this could point toward a new treatment option for mobility problems in people with vascular parkinsonism or related conditions.
- What could go wrong
- This is a small, early exploratory study. The results may not apply to everyone, and dalfampridine can cause side effects like seizures or dizziness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
72 people
The number who actually took part.
- Started
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Aug 2023
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with insidious-onset vascular parkinsonism or Parkinson-plus syndromes, with gait impairment and poor levodopa response.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Clinical diagnosis of insidious-onset vascular parkinsonism or Parkinson-plus syndromes * Gait, balance, or mobility impairment * Poor levodopa response (\<10% improvement in UPDRS-III after levodopa challenge) * Ability to complete all study assessments Exclusion Criteria: * Seizure disorder or epilepsy * Multiple sclerosis * Repeated traumatic brain injury * Encephalitis, brain tumor, or normal-pressure hydrocephalus * Severe peripheral neuropathy * Severe systemic illness or active infection * Other neurological/psychiatric conditions interfering with assessments
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Tangdu Hospital, Fourth Military Medical University
Xi'an, Shaanxi, 710038, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.