Skin biopsies shed light on rare blood vessel disease
NCT ID NCT03004326
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at skin samples from 50 people with different types of vasculitis, a condition where blood vessels become inflamed. Researchers want to understand how the disease affects the skin at a molecular level. Participants must have an active skin rash related to their vasculitis. No new treatments are being tested; the goal is to gather information to improve future diagnosis and care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jan 2017
- Expected to finish
-
Dec 2028
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
About 56 people with vasculitis will take part in this study at approximately 20 medical centers across North America. Patients with CV, DiV, EGPA, IgA vasculitis, GPA, MPA, PAN, isolated cutaneous vasculitis and urticarial vasculitis will potentially be enrolled into this study. The protocol will be conducted at the major vasculitis centers in the United States and Canada participating in selected VCRC studies. Skin biopsy specimens collected as standard of care for these diseases will be retrieved and used in research.
- Ages
-
5 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis * Have a suspected or confirmed diagnosis of: * Cryoglobulinemic vasculitis (CV) * Drug-induced vasculitis * Eosinophilic granulomatosis with polyangiitis (EGPA) * IgA vasculitis * Isolated cutaneous vasculitis * Granulomatosis with polyangiitis (GPA) * Microscopic polyangiitis (MPA) * Polyarteritis nodosa (PAN) * Urticarial vasculitis * Be willing and able to provide written informed consent (or assent for those under Exclusion Criteria: * You are less than five years old * Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy * You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL * You have an uncontrolled disease that could prevent you from completing the study procedures * You have an active infection at or near the potential biopsy site, have poor circulation, or have bony prominence or other structure that would increase your risk of complications if you participated in this study * You are pregnant or nursing * You are not able to provide informed consent
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Cryoglobulinemic vasculitis (CV) are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
4 sites in 2 countries. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
Boston University School of Medicine
COMPLETEDBoston, Massachusetts, 02118, United States
-
Cleveland Clinic
COMPLETEDCleveland, Ohio, 44195, United States
-
Mayo Clinic
COMPLETEDRochester, Minnesota, 55905, United States
-
Oregon Health & Science University
COMPLETEDPortland, Oregon, United States
-
St. Joseph's Healthcare
RECRUITINGHamilton, Ontario, Canada
-
University of California, Los Angeles
COMPLETEDLos Angeles, California, 90095, United States
-
University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
-
University of Toronto Mount Sinai Hospital
RECRUITINGToronto, Ontario, M5G 1X5, Canada
-
University of Utah
COMPLETEDSalt Lake City, Utah, United States
-
University of Virginia
RECRUITINGCharlottesville, Virginia, 22903, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a biologic drug tame a rare vasculitis and cut steroid use?
- Cancer immunotherapy can attack the heart: massive data hunt seeks who is most vulnerable
- Can better sleep ease pain in teens with rheumatic disease?
- Could an arthritis drug shrink dangerous brain aneurysms?
- New study aims to spot eye damage early in rare vasculitis patients
- Blood test may spot hidden gut trouble in kids with rare disease