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Turmeric compound tested to keep Crohn's at bay after surgery

NCT ID NCT02255370

Prevention Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether curcumin, the active ingredient in turmeric, can prevent Crohn's disease from coming back after surgery. 61 adults who had recent surgery for Crohn's were given either curcumin or a placebo, along with standard thiopurine drugs, for 6 months. The goal was to see if curcumin could reduce inflammation and recurrence better than placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
curcumin
What this could lead to
If it works, this could offer a natural alternative to standard drugs for preventing Crohn's disease from coming back after surgery.
What could go wrong
This is a small, completed trial with only 61 participants. Curcumin may not be as effective as current treatments, and results may not apply to everyone with Crohn's.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

61 people

The number who actually took part.

Started

Dec 2014

Finished

Jun 2018

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Crohn's disease confirmed by radiographic, endoscopic or histologic criteria * Age \> 18 yr * Affiliated to french health insurance * Operated on less than 15 days ago for ileal, colonic or ileo-colonic Crohn's disease with all macroscopic lesions being removed, with an anastomosis which can be reached by ileocolonoscopy Exclusion Criteria: * Ulcerative colitis * Pregnant or nursing woman * Refusal of contraceptive measure for childbearing potential, woman or fertile man * Indication of anti-TNFα treatment * Concomitant treatment including antibiotics, probiotics, mesalazine, methotrexate, cyclosporine, tacrolimus, anti-TNFα, ustekinumab, vedolizumab * Concomitant treatment with corticosteroids, except in case of tapering a treatment initiated before surgery * Renal insufficiency ( serum creatinine 2N) * Chronic hepatic disease except for primary sclerosing cholangitis * ALAT , ASAT, alkaline phosphatases, or bilirubin \> 3N * Current infection to HIV, HBV (except if HBV Ac positives), HCV * Contraindication to thiopurines * Unwillingness of the patient

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Conditions

The condition(s) this trial relates to.

Crohn disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Crohn's disease

Contacts and locations

Locations

  • CHU de Clermont-Ferrand

    Clermont-Ferrand, 63003, France

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Other studies related to the condition(s) this trial covers.