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Turmeric power: could curcumin nanogels replace steroids for a painful mouth condition?

NCT ID NCT06932848

Disease control Sponsor: Chulalongkorn University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares curcumin nanogels (a natural turmeric extract) to a standard steroid paste for treating atrophic-erosive oral lichen planus, a chronic inflammatory mouth condition. Thirty adults will apply either treatment three times daily for four weeks. Researchers will measure changes in disease activity and patient satisfaction, hoping to find a gentler, effective option.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
curcumin in nanogels
What this could lead to
If it works, this could offer a natural, better-tolerated alternative to steroid treatment for managing oral lichen planus symptoms.
What could go wrong
This is a small, early-stage trial with only 30 participants. Curcumin may prove less effective than the standard steroid, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Ability to provide written informed consent * Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP) * Presence of symptoms (NRS pain score \> 0 at baseline) * Ability to communicate and follow instructions * Willingness to apply oral paste treatment and comply with study protocol Exclusion Criteria: * Pregnancy or lactation * Current orthodontic treatment * Uncontrolled diabetes mellitus (HbA1c \> 7% or FPG \> 130 mg/dL) * Use of anticoagulants or antiplatelet agents * Severe dry mouth (Challacombe score \> 7) * History of gastric ulcers, duodenal ulcers, or gallstones * Presence of any active malignancy or infection * Use of topical/systemic treatment for OLP in the past 2 weeks * Current use of immunosuppressants * Known allergy to corticosteroids or herbal agents such as turmeric * Diagnosis of oral lichenoid contact lesion or graft-versus-host disease (GVHD) * History of allogeneic bone marrow transplantation * Current smokers

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Conditions

The condition(s) this trial relates to.

autoimmune disease lichen planus, oral oral erosive lichen

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oral lichen planus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry, Chulalongkorn University

    RECRUITING

    Bangkok, 10400, Thailand

More trials for these conditions

Other studies related to the condition(s) this trial covers.