Spice and tea combo tested for stomach troubles
NCT ID NCT07052890
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a supplement containing curcumin, green tea, and vitamin D could help control symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D). 78 adults with IBS-D took either the supplement or a placebo for 4 weeks, followed by 4 weeks where everyone got the supplement. The main goal was to see if symptoms like belly pain and bloating improved more with the supplement than with placebo.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a dietary supplement containing curcumin, green tea extract, and vitamin D3
- What this could lead to
- If it works, this could offer a natural, over-the-counter option to help control IBS-D symptoms like belly pain and diarrhea.
- What could go wrong
- This is a small, early-stage trial with only 78 people and a short 4-week treatment period, so results may not apply to everyone. Supplements are not strictly regulated, and individual responses can vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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78 people
The number who actually took part.
- Started
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Sep 2024
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Participant has provided written informed consent before participating in the study after being given a full description of the study and prior to any study-specific procedures being performed. 2. Participant has irritable bowel syndrome with diarrhoea (IBS-D), as defined by the Rome IV criteria. 3. Participant has an IBS-SSS score of \>175 at screening. 4. Participant is a male or non-pregnant female and is ≥18 years of age 5. Participant can communicate well with the Investigator and to comply with the requirements for the entire study. 6. Participant has capacity to understand written English. 7. Participant has a body mass index (BMI) of 18.5 - 39.9kg/m2 (bounds included). 8. Participant agrees to follow all pre-test preparation before breath testing visits. Exclusion Criteria: 1. Prior abdominal surgery other than appendectomy and cholecystectomy. 2. Known hypercalcaemia. 3. Participating in another trial or taken an IMP within the last 1 month. 4. Females who report to be pregnant or lactating 5. Unwilling to maintain stable doses of permitted concomitant medication 6. Unwilling to maintain a stable diet for the duration of the trial 7. Being in the opinion of the investigator unsuitable 8. Insufficient knowledge of English to complete the daily bowel diary and food diary 9. Hypersensitivity to any component of the supplement 10. Hypersensitivity or known allergy to lactulose 11. Drug interactions with any component of the supplement 12. Consumption of antibiotics, prebiotics or probiotics (in food products or as supplements) in the last 4 weeks prior to, or during the study. 13. Vitamin D two week washout 14. Participants who have received bowel preparation for investigative procedures in the 4 weeks prior to the study 15. Individuals declaring additional specific dietary needs 16. Inflammatory bowel disease or coeliac disease 17. Any other condition, deemed by the investigator, that may be causing their symptoms 18. No major co-morbidity. 19. Participant is involved in this study as an Investigator, sub-Investigator, study coordinator, other study staff, or Sponsor member.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The Functional Gut Clinic Cambridge
Cambridge, CB2 1LR, United Kingdom
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The Functional Gut Clinic London
London, NW1 6PU, United Kingdom
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The Functional Gut Clinic Manchester
Manchester, m3 4bg, United Kingdom
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