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Spice and tea combo tested for stomach troubles

NCT ID NCT07052890

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a supplement containing curcumin, green tea, and vitamin D could help control symptoms in people with diarrhea-predominant irritable bowel syndrome (IBS-D). 78 adults with IBS-D took either the supplement or a placebo for 4 weeks, followed by 4 weeks where everyone got the supplement. The main goal was to see if symptoms like belly pain and bloating improved more with the supplement than with placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a dietary supplement containing curcumin, green tea extract, and vitamin D3
What this could lead to
If it works, this could offer a natural, over-the-counter option to help control IBS-D symptoms like belly pain and diarrhea.
What could go wrong
This is a small, early-stage trial with only 78 people and a short 4-week treatment period, so results may not apply to everyone. Supplements are not strictly regulated, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

78 people

The number who actually took part.

Started

Sep 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participant has provided written informed consent before participating in the study after being given a full description of the study and prior to any study-specific procedures being performed. 2. Participant has irritable bowel syndrome with diarrhoea (IBS-D), as defined by the Rome IV criteria. 3. Participant has an IBS-SSS score of \>175 at screening. 4. Participant is a male or non-pregnant female and is ≥18 years of age 5. Participant can communicate well with the Investigator and to comply with the requirements for the entire study. 6. Participant has capacity to understand written English. 7. Participant has a body mass index (BMI) of 18.5 - 39.9kg/m2 (bounds included). 8. Participant agrees to follow all pre-test preparation before breath testing visits. Exclusion Criteria: 1. Prior abdominal surgery other than appendectomy and cholecystectomy. 2. Known hypercalcaemia. 3. Participating in another trial or taken an IMP within the last 1 month. 4. Females who report to be pregnant or lactating 5. Unwilling to maintain stable doses of permitted concomitant medication 6. Unwilling to maintain a stable diet for the duration of the trial 7. Being in the opinion of the investigator unsuitable 8. Insufficient knowledge of English to complete the daily bowel diary and food diary 9. Hypersensitivity to any component of the supplement 10. Hypersensitivity or known allergy to lactulose 11. Drug interactions with any component of the supplement 12. Consumption of antibiotics, prebiotics or probiotics (in food products or as supplements) in the last 4 weeks prior to, or during the study. 13. Vitamin D two week washout 14. Participants who have received bowel preparation for investigative procedures in the 4 weeks prior to the study 15. Individuals declaring additional specific dietary needs 16. Inflammatory bowel disease or coeliac disease 17. Any other condition, deemed by the investigator, that may be causing their symptoms 18. No major co-morbidity. 19. Participant is involved in this study as an Investigator, sub-Investigator, study coordinator, other study staff, or Sponsor member.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • The Functional Gut Clinic Cambridge

    Cambridge, CB2 1LR, United Kingdom

  • The Functional Gut Clinic London

    London, NW1 6PU, United Kingdom

  • The Functional Gut Clinic Manchester

    Manchester, m3 4bg, United Kingdom

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