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Chilled solution or steroid: which eases Post-Root-Canal pain?

NCT ID NCT07738302

Symptom relief Sponsor: Suez Canal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether using cold irrigation solutions or adding dexamethasone during root canal treatment can lower post-operative pain in people with symptomatic irreversible pulpitis and acute apical periodontitis. Sixty medically healthy adults aged 20-50 will be randomly assigned to receive one of four irrigation combinations. The study measures pain levels using a visual analogue scale to see if these approaches reduce discomfort after the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cold sodium hypochlorite (NaOCl) and dexamethasone, used as irrigation solutions during root canal treatment
What this could lead to
If effective, this could offer a simple, drug-sparing way to reduce pain after root canal procedures, potentially improving patient comfort and recovery.
What could go wrong
This is a small, early-stage trial, and results may not apply to all patients. Cold irrigation or dexamethasone may not significantly reduce pain compared to standard care, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Medically free Patients. (ASA I and II) * Age between 20-50 years old. * Males \& Females. * Patients' acceptance for participating in the trial through an informed consent (Appendix I) * Diagnosed clinically and radiographically with symptomatic irreversible pulpitis with apical peridontitits * No periapical radiolucency * Patent canals with n Exclusion Criteria: Non restorable teeth. * No bleeding upon conducting access preparation. * Teeth presenting with: * History of trauma or previous endodontic treatment

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post operative pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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Other studies related to the condition(s) this trial covers.