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Cold therapy may ease root canal pain, new study suggests

NCT ID NCT07403578

Symptom relief Sponsor: TC Erciyes University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether applying cold (cryotherapy) to the gums right after a numbing shot can make root canal treatment less painful. About 100 adults with an infected lower premolar tooth will be randomly assigned to receive standard numbing methods with or without the cold treatment. The goal is to see if the cold helps the numbing work better and reduces pain during the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemically healthy patients classified as ASA I or II, aged between 18 and 60 years, * Presence of a restorable mandibular premolar tooth diagnosed with symptomatic irreversible pulpitis, * History of spontaneous pain or lingering pain elicited by thermal stimuli, * Positive response with lingering pain to cold testing (Endo Ice; Coltene, Altstätten, Switzerland), * Positive response at low current levels to electric pulp testing (Parkell Inc., USA), * Teeth with closed apex and no radiographic evidence of periapical pathology (intact periodontal ligament space and absence of periapical radiolucency), * Patients presenting with moderate or severe preoperative pain, as assessed using the visual analogue scale (VAS). Exclusion Criteria: * Patients who had taken analgesic, anti-inflammatory, or opioid medication within the last 12 hours before treatment, * Patients with systemic conditions that may affect pain perception, inflammatory response, or healing, * History of antibiotic use within the previous month or requirement for antibiotic prophylaxis, * Teeth presenting with clinical or radiographic signs of pulp necrosis or apical periodontitis (Pain on percussion or palpation, presence of sinus tract or swelling, presence of periapical radiolucency), * Teeth with root resorption, immature apices, severe coronal destruction preventing proper isolation, or calcified canals, * Teeth that had undergone previous endodontic treatment, including pulpotomy or root canal filling, * Patients with neurological or psychiatric conditions that could interfere with pain perception or accurate pain reporting, * Inability to achieve adequate isolation with a rubberdam.

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Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cryotherapy Irreversible pulpitis

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  2. A doctor treating you

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More trials for these conditions

Other studies related to the condition(s) this trial covers.